Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy

Magnetite nanoparticles are one of the most promising ferrofluids for hyperthermia applications due to the combination of unique physicochemical and magnetic properties. In this study, we designed and produced superparamagnetic ferrofluids composed of magnetite (Fe3O4, MION) and cobalt-doped magneti...

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Detalles Bibliográficos
Autores: Alice Gameiro Leonel, Alexandra Ancelmo Piscitelli Mansur, Sandhra Maria de Carvalho, Luis Eugenio Fernandez Outon, Jose Domingos Ardisson, Klaus Wilhelm Heinrich Krambrock, Herman Sander Mansur
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Brasil
Institución:Universidade Federal de Minas Gerais (UFMG)
Repositorio:Repositório Institucional da UFMG
Idioma:inglés
OAI Identifier:oai:repositorio.ufmg.br:1843/80446
Acceso en línea:https://doi.org/10.1039/d0na00820f
http://hdl.handle.net/1843/80446
https://orcid.org/0000-0002-8798-4182
https://orcid.org/0000-0003-1526-2508
https://orcid.org/0000-0001-6665-8647
https://orcid.org/0000-0003-3264-337X
https://orcid.org/0000-0002-7562-0285
https://orcid.org/0000-0002-3032-495X
Access Level:acceso abierto
Palabra clave:Magnetite nanoparticles
Cancer
Magnetita
Nanopartículas
Câncer
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spelling Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapyMagnetite nanoparticlesMagnetite nanoparticlesCancerCancerMagnetitaNanopartículasCâncerMagnetite nanoparticles are one of the most promising ferrofluids for hyperthermia applications due to the combination of unique physicochemical and magnetic properties. In this study, we designed and produced superparamagnetic ferrofluids composed of magnetite (Fe3O4, MION) and cobalt-doped magnetite (Cox-MION, x = 3, 5, and 10% mol of cobalt) nanoconjugates through an eco-friendly aqueous method using carboxymethylcellulose (CMC) as the biocompatible macromolecular ligand. The effect of the gradual increase of cobalt content in Fe3O4 nanocolloids was investigated in-depth using XRD, XRF, XPS, FTIR, DLS, zeta potential, EMR, and VSM analyses. Additionally, the cytotoxicity of these nanoconjugates and their ability to cause cancer cell death through heat induction were evaluated by MTT assays in vitro. The results demonstrated that the progressive substitution of Co in the magnetite host material significantly affected the magnetic anisotropy properties of the ferrofluids. Therefore, Co-doped ferrite (CoxFe(3−x)O4) nanoconjugates enhanced the cell-killing activities in magnetic hyperthermia experiments under alternating magnetic field performed with human brain cancer cells (U87). On the other hand, the Co-doping process retained the pristine inverse spinel crystalline structure of MIONs, and it has not significantly altered the average nanoparticle size (ca.∼7.1 ± 1.6 nm). Thus, the incorporation of cobalt into magnetite-polymer nanostructures may constitute a smart strategy for tuning their magnetothermal capability towards cancer therapy by heat generation.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e ProjetosUniversidade Federal de Minas GeraisBrasilENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICAICX - DEPARTAMENTO DE FÍSICAUFMG2025-02-26T11:18:55Z2025-02-26T11:18:55Z2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdfhttps://doi.org/10.1039/d0na00820f2516-0230http://hdl.handle.net/1843/80446https://orcid.org/0000-0002-8798-4182https://orcid.org/0000-0003-1526-2508https://orcid.org/0000-0001-6665-8647https://orcid.org/0000-0003-3264-337Xhttps://orcid.org/0000-0002-7562-0285https://orcid.org/0000-0002-3032-495XengNanoscale Advancesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGAlice Gameiro LeonelAlexandra Ancelmo Piscitelli MansurSandhra Maria de CarvalhoLuis Eugenio Fernandez OutonJose Domingos ArdissonKlaus Wilhelm Heinrich KrambrockHerman Sander Mansur2025-03-07T20:04:32Zoai:repositorio.ufmg.br:1843/80446Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2025-03-07T20:04:32Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
title Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
spellingShingle Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
Alice Gameiro Leonel
Magnetite nanoparticles
Magnetite nanoparticles
Cancer
Cancer
Magnetita
Nanopartículas
Câncer
title_short Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
title_full Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
title_fullStr Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
title_full_unstemmed Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
title_sort Tunable magnetothermal properties of cobalt-doped magnetite-carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy
dc.creator.none.fl_str_mv Alice Gameiro Leonel
Alexandra Ancelmo Piscitelli Mansur
Sandhra Maria de Carvalho
Luis Eugenio Fernandez Outon
Jose Domingos Ardisson
Klaus Wilhelm Heinrich Krambrock
Herman Sander Mansur
author Alice Gameiro Leonel
author_facet Alice Gameiro Leonel
Alexandra Ancelmo Piscitelli Mansur
Sandhra Maria de Carvalho
Luis Eugenio Fernandez Outon
Jose Domingos Ardisson
Klaus Wilhelm Heinrich Krambrock
Herman Sander Mansur
author_role author
author2 Alexandra Ancelmo Piscitelli Mansur
Sandhra Maria de Carvalho
Luis Eugenio Fernandez Outon
Jose Domingos Ardisson
Klaus Wilhelm Heinrich Krambrock
Herman Sander Mansur
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Magnetite nanoparticles
Magnetite nanoparticles
Cancer
Cancer
Magnetita
Nanopartículas
Câncer
topic Magnetite nanoparticles
Magnetite nanoparticles
Cancer
Cancer
Magnetita
Nanopartículas
Câncer
description Magnetite nanoparticles are one of the most promising ferrofluids for hyperthermia applications due to the combination of unique physicochemical and magnetic properties. In this study, we designed and produced superparamagnetic ferrofluids composed of magnetite (Fe3O4, MION) and cobalt-doped magnetite (Cox-MION, x = 3, 5, and 10% mol of cobalt) nanoconjugates through an eco-friendly aqueous method using carboxymethylcellulose (CMC) as the biocompatible macromolecular ligand. The effect of the gradual increase of cobalt content in Fe3O4 nanocolloids was investigated in-depth using XRD, XRF, XPS, FTIR, DLS, zeta potential, EMR, and VSM analyses. Additionally, the cytotoxicity of these nanoconjugates and their ability to cause cancer cell death through heat induction were evaluated by MTT assays in vitro. The results demonstrated that the progressive substitution of Co in the magnetite host material significantly affected the magnetic anisotropy properties of the ferrofluids. Therefore, Co-doped ferrite (CoxFe(3−x)O4) nanoconjugates enhanced the cell-killing activities in magnetic hyperthermia experiments under alternating magnetic field performed with human brain cancer cells (U87). On the other hand, the Co-doping process retained the pristine inverse spinel crystalline structure of MIONs, and it has not significantly altered the average nanoparticle size (ca.∼7.1 ± 1.6 nm). Thus, the incorporation of cobalt into magnetite-polymer nanostructures may constitute a smart strategy for tuning their magnetothermal capability towards cancer therapy by heat generation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2025-02-26T11:18:55Z
2025-02-26T11:18:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1039/d0na00820f
2516-0230
http://hdl.handle.net/1843/80446
https://orcid.org/0000-0002-8798-4182
https://orcid.org/0000-0003-1526-2508
https://orcid.org/0000-0001-6665-8647
https://orcid.org/0000-0003-3264-337X
https://orcid.org/0000-0002-7562-0285
https://orcid.org/0000-0002-3032-495X
url https://doi.org/10.1039/d0na00820f
http://hdl.handle.net/1843/80446
https://orcid.org/0000-0002-8798-4182
https://orcid.org/0000-0003-1526-2508
https://orcid.org/0000-0001-6665-8647
https://orcid.org/0000-0003-3264-337X
https://orcid.org/0000-0002-7562-0285
https://orcid.org/0000-0002-3032-495X
identifier_str_mv 2516-0230
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanoscale Advances
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
ICX - DEPARTAMENTO DE FÍSICA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA
ICX - DEPARTAMENTO DE FÍSICA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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score 15.300719

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