Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis
Objective: Evaluate and correlate data between relevant cytokines, disease progression, and handgrip and quality of life among RA patients at different stages of disease progression. Method: Thirty-three RA patients were recruited for analysis, using comparisons and correlations, between levels of c...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | Brasil |
| Institución: | Hospital de Clínicas de Itajubá |
| Repositorio: | Revista Ciências em Saúde |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.portalrcs.hcitajuba.org.br:article/1493 |
| Acceso en línea: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e1493 |
| Access Level: | acceso abierto |
| Palabra clave: | Rheumatoid Artrits Quality of Life Pain DAS-28 SF-36 Hand Strength Artrite Reumatóide Qualidade de Vida Dor Força da Mão |
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Brasil |
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| dc.title.none.fl_str_mv |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis Qualidade de vida e força, porém não as citocinas, estão associadas ao DAS-28 em pacientes com artrite reumatoide na fase ativa e inativa |
| title |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| spellingShingle |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis Travizan, Marina Rheumatoid Artrits Quality of Life Pain DAS-28 SF-36 Hand Strength Artrite Reumatóide Qualidade de Vida Dor DAS-28 SF-36 Força da Mão |
| title_short |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| title_full |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| title_fullStr |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| title_full_unstemmed |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| title_sort |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritis |
| dc.creator.none.fl_str_mv |
Travizan, Marina Vitaliano Graminha, Cristiane Molinero Andrade Ratkevicius, Cristhiane Farnesi Assunção, Thaís Soares Botelho Teodoro, Reginaldo Stefenoni Krüger, Gabriella Jerônimo, Erik Augusto Pessato Timóteo, Rodolfo |
| author |
Travizan, Marina |
| author_facet |
Travizan, Marina Vitaliano Graminha, Cristiane Molinero Andrade Ratkevicius, Cristhiane Farnesi Assunção, Thaís Soares Botelho Teodoro, Reginaldo Stefenoni Krüger, Gabriella Jerônimo, Erik Augusto Pessato Timóteo, Rodolfo |
| author_role |
author |
| author2 |
Vitaliano Graminha, Cristiane Molinero Andrade Ratkevicius, Cristhiane Farnesi Assunção, Thaís Soares Botelho Teodoro, Reginaldo Stefenoni Krüger, Gabriella Jerônimo, Erik Augusto Pessato Timóteo, Rodolfo |
| author2_role |
author author author author author author author |
| dc.subject.por.fl_str_mv |
Rheumatoid Artrits Quality of Life Pain DAS-28 SF-36 Hand Strength Artrite Reumatóide Qualidade de Vida Dor DAS-28 SF-36 Força da Mão |
| topic |
Rheumatoid Artrits Quality of Life Pain DAS-28 SF-36 Hand Strength Artrite Reumatóide Qualidade de Vida Dor DAS-28 SF-36 Força da Mão |
| description |
Objective: Evaluate and correlate data between relevant cytokines, disease progression, and handgrip and quality of life among RA patients at different stages of disease progression. Method: Thirty-three RA patients were recruited for analysis, using comparisons and correlations, between levels of circulating cytokines (IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17, IL-1β, and TNF receptors I and II), activity of the disease (evaluated using the DAS-28), handgrip (Hydraulic dynamometer), and quality of life (SF-36). Result: RA patients in different disease stages showed increases of IL-6 and IL-10 compared control group. Positive correlation between IL-6 with TNF-α, and IL-4 with IL-10 was found. Handgrip strength and quality of life were not related to cytokine levels. However, remission patients had better strength and quality of life indices compared to the active patients. In addition, handgrip of the non-dominant side, physical functions, role limitations physical health, pain, energy/fatigue and social functions have a negative correlation with the DAS28-PCR. Conclusion: High levels of IL-6 and IL-10 were observed in the chronic RA patients, but the values did not show correlation with disease activity, handgrip strength and quality of life. Disease activity show correlation with handgrip strength and quality of life. Furthermore, remission patients had better strength and quality of life indices compared to the active patients. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-05-16 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer reviewed Avaliado pelos pares info:eu-repo/semantics/other |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e1493 10.21876/hsjhci.v14.2024.e1493 |
| url |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e1493 |
| identifier_str_mv |
10.21876/hsjhci.v14.2024.e1493 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e1493/928 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Hospital de Clínicas de Itajubá |
| publisher.none.fl_str_mv |
Hospital de Clínicas de Itajubá |
| dc.source.none.fl_str_mv |
HSJ; Vol. 14 (2024): Volume 14 - 2024; e1493 HSJ; v. 14 (2024): Volume 14 - 2024; e1493 2966-0408 10.21876/hsjhci.v14 reponame:Revista Ciências em Saúde instname:Hospital de Clínicas de Itajubá instacron:HCI |
| instname_str |
Hospital de Clínicas de Itajubá |
| instacron_str |
HCI |
| institution |
HCI |
| reponame_str |
Revista Ciências em Saúde |
| collection |
Revista Ciências em Saúde |
| repository.name.fl_str_mv |
Revista Ciências em Saúde - Hospital de Clínicas de Itajubá |
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rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br |
| _version_ |
1853661995438440448 |
| spelling |
Quality of life and strength, but not cytokines, are associated with DAS-28 in active and inactive rheumatoid arthritisQualidade de vida e força, porém não as citocinas, estão associadas ao DAS-28 em pacientes com artrite reumatoide na fase ativa e inativaRheumatoid ArtritsQuality of LifePainDAS-28SF-36Hand StrengthArtrite ReumatóideQualidade de VidaDorDAS-28SF-36Força da MãoObjective: Evaluate and correlate data between relevant cytokines, disease progression, and handgrip and quality of life among RA patients at different stages of disease progression. Method: Thirty-three RA patients were recruited for analysis, using comparisons and correlations, between levels of circulating cytokines (IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17, IL-1β, and TNF receptors I and II), activity of the disease (evaluated using the DAS-28), handgrip (Hydraulic dynamometer), and quality of life (SF-36). Result: RA patients in different disease stages showed increases of IL-6 and IL-10 compared control group. Positive correlation between IL-6 with TNF-α, and IL-4 with IL-10 was found. Handgrip strength and quality of life were not related to cytokine levels. However, remission patients had better strength and quality of life indices compared to the active patients. In addition, handgrip of the non-dominant side, physical functions, role limitations physical health, pain, energy/fatigue and social functions have a negative correlation with the DAS28-PCR. Conclusion: High levels of IL-6 and IL-10 were observed in the chronic RA patients, but the values did not show correlation with disease activity, handgrip strength and quality of life. Disease activity show correlation with handgrip strength and quality of life. Furthermore, remission patients had better strength and quality of life indices compared to the active patients.Objetivo: Avaliar e correlacionar dados entre citocinas relevantes, progressão da doença, preensão manual e qualidade de vida entre pacientes com AR em diferentes estágios de progressão da doença. Método: Trinta e três pacientes com AR foram recrutados para análise, por meio de comparações e correlações, entre níveis de citocinas circulantes (IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17, IL-1β e receptores de TNF-I e -II), atividade da doença (avaliada pelo DAS-28), preensão manual (dinamômetro hidráulico) e qualidade de vida (SF-36). Resultado: Pacientes com doença ativa e inativa apresentaram aumento de IL-6 e IL-10 comparados ao grupo controle. Foi encontrada correlação positiva entre IL-6 com TNF-α e IL-4 com IL-10. A força de preensão e a qualidade de vida não relacionaram aos níveis de citocinas. Entretanto, pacientes em remissão apresentaram melhores índices de força e qualidade de vida comparados aos pacientes com doença ativa. Além disso, preensão manual do lado não dominante, e quesitos dos SF-36, apresentam correlação negativa com o DAS28- PCR. Conclusão: Foram observados níveis elevados de IL-6 e IL-10 nos pacientes com AR crônica, mas os valores não mostraram correlação com DAS-28, força de preensão manual e SF-36. A atividade da doença apresenta correlação com força de preensão manual e qualidade de vida. Além disso, os pacientes em remissão apresentaram melhores índices de força e qualidade de vida em comparação aos pacientes ativos.Hospital de Clínicas de Itajubá2024-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos paresinfo:eu-repo/semantics/otherapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e149310.21876/hsjhci.v14.2024.e1493HSJ; Vol. 14 (2024): Volume 14 - 2024; e1493HSJ; v. 14 (2024): Volume 14 - 2024; e14932966-040810.21876/hsjhci.v14reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIenghttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/hsjhci.v14.2024.e1493/928Copyright (c) 2024 Marina Travizan, Cristiane Vitaliano Graminha, Cristhiane Molinero Andrade Ratkevicius, Thaís Soares Farnesi Assunção, Reginaldo Botelho Teodoro, Gabriella Stefenoni Krüger, Erik Augusto Jerônimo, Rodolfo Pessato Timóteoinfo:eu-repo/semantics/openAccessTravizan, MarinaVitaliano Graminha, CristianeMolinero Andrade Ratkevicius, CristhianeFarnesi Assunção, Thaís SoaresBotelho Teodoro, ReginaldoStefenoni Krüger, GabriellaJerônimo, Erik AugustoPessato Timóteo, Rodolfo2024-06-10T17:37:29Zoai:ojs.portalrcs.hcitajuba.org.br:article/1493Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2024-06-10T17:37:29Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse |
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15.300724 |