H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling
Background: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. Methods: Metabolomic profiling, employing H-1-NMR, H-1-NMR -T-2-edited, and 2D-NMR spectroscopy an...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/53670 |
| Acceso en línea: | http://dx.doi.org/10.1186/s40345-017-0088-2 https://repositorio.unifesp.br/handle/11600/53670 |
| Access Level: | acceso abierto |
| Palabra clave: | H-1-NMR Biomarkers Bipolar disorder Metabolic profiling Chemometrics 2D NMR |
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H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profilingH-1-NMRBiomarkersBipolar disorderMetabolic profilingChemometrics2D NMRBackground: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. Methods: Metabolomic profiling, employing H-1-NMR, H-1-NMR -T-2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. Results: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). In addition, amygdalin, alpha-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology. Conclusions: The strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up.Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, BrazilISCMSP, Dept Psychiat, Rua Major Maragliano 287, BR-04017030 Sao Paulo, BrazilUniv Estadual Campinas UNICAMP, Lab Quim Biol, Dept Organ Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, BrazilUniv Estadual Campinas UNICAMP, Dept Analyt Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil)FAPESPCNPqFAPESP: 2014/18938-8Springer Heidelberg2020-06-26T16:30:37Z2020-06-26T16:30:37Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1186/s40345-017-0088-2International Journal Of Bipolar Disorders. Heidelberg, v. 5, p. -, 2017.10.1186/s40345-017-0088-2WOS000403186100001.pdf2194-7511https://repositorio.unifesp.br/handle/11600/53670WOS:000403186100001ark:/48912/001300001p82xengInternational Journal Of Bipolar DisordersHeidelberginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPSethi, Sumit [UNIFESP]Pedrini, Mariana [UNIFESP]Rizzo, Lucas B. [UNIFESP]Zeni-Graiff, Maiara [UNIFESP]Dal Mas, Caroline [UNIFESP]Cassinelli, Ana ClaudiaNoto, Mariane N. [UNIFESP]Asevedo, Elson [UNIFESP]Cordeiro, QuirinoPontes, Joao G. M.Brasil, Antonio J. M.Lacerda, Acioly [UNIFESP]Hayashi, Mirian A. F. [UNIFESP]Poppi, RoneiTasic, LjubicaBrietzke, Elisa [UNIFESP]2024-08-11T01:56:09Zoai:repositorio.unifesp.br:11600/53670Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T01:56:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| title |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| spellingShingle |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling Sethi, Sumit [UNIFESP] H-1-NMR Biomarkers Bipolar disorder Metabolic profiling Chemometrics 2D NMR |
| title_short |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| title_full |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| title_fullStr |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| title_full_unstemmed |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| title_sort |
H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling |
| dc.creator.none.fl_str_mv |
Sethi, Sumit [UNIFESP] Pedrini, Mariana [UNIFESP] Rizzo, Lucas B. [UNIFESP] Zeni-Graiff, Maiara [UNIFESP] Dal Mas, Caroline [UNIFESP] Cassinelli, Ana Claudia Noto, Mariane N. [UNIFESP] Asevedo, Elson [UNIFESP] Cordeiro, Quirino Pontes, Joao G. M. Brasil, Antonio J. M. Lacerda, Acioly [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] Poppi, Ronei Tasic, Ljubica Brietzke, Elisa [UNIFESP] |
| author |
Sethi, Sumit [UNIFESP] |
| author_facet |
Sethi, Sumit [UNIFESP] Pedrini, Mariana [UNIFESP] Rizzo, Lucas B. [UNIFESP] Zeni-Graiff, Maiara [UNIFESP] Dal Mas, Caroline [UNIFESP] Cassinelli, Ana Claudia Noto, Mariane N. [UNIFESP] Asevedo, Elson [UNIFESP] Cordeiro, Quirino Pontes, Joao G. M. Brasil, Antonio J. M. Lacerda, Acioly [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] Poppi, Ronei Tasic, Ljubica Brietzke, Elisa [UNIFESP] |
| author_role |
author |
| author2 |
Pedrini, Mariana [UNIFESP] Rizzo, Lucas B. [UNIFESP] Zeni-Graiff, Maiara [UNIFESP] Dal Mas, Caroline [UNIFESP] Cassinelli, Ana Claudia Noto, Mariane N. [UNIFESP] Asevedo, Elson [UNIFESP] Cordeiro, Quirino Pontes, Joao G. M. Brasil, Antonio J. M. Lacerda, Acioly [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] Poppi, Ronei Tasic, Ljubica Brietzke, Elisa [UNIFESP] |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.por.fl_str_mv |
H-1-NMR Biomarkers Bipolar disorder Metabolic profiling Chemometrics 2D NMR |
| topic |
H-1-NMR Biomarkers Bipolar disorder Metabolic profiling Chemometrics 2D NMR |
| description |
Background: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. Methods: Metabolomic profiling, employing H-1-NMR, H-1-NMR -T-2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. Results: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). In addition, amygdalin, alpha-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology. Conclusions: The strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2020-06-26T16:30:37Z 2020-06-26T16:30:37Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s40345-017-0088-2 International Journal Of Bipolar Disorders. Heidelberg, v. 5, p. -, 2017. 10.1186/s40345-017-0088-2 WOS000403186100001.pdf 2194-7511 https://repositorio.unifesp.br/handle/11600/53670 WOS:000403186100001 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001p82x |
| url |
http://dx.doi.org/10.1186/s40345-017-0088-2 https://repositorio.unifesp.br/handle/11600/53670 |
| identifier_str_mv |
International Journal Of Bipolar Disorders. Heidelberg, v. 5, p. -, 2017. 10.1186/s40345-017-0088-2 WOS000403186100001.pdf 2194-7511 WOS:000403186100001 ark:/48912/001300001p82x |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
International Journal Of Bipolar Disorders |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.coverage.none.fl_str_mv |
Heidelberg |
| dc.publisher.none.fl_str_mv |
Springer Heidelberg |
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Springer Heidelberg |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1853670475973001216 |
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15.301603 |