The Diamond STING Server.

Diamond STING is a new version of the STING suite of programs for a comprehensive analysis of a relationship between protein sequence, structure, function and stability. We have added a number of new functionalities by both providing more structure parameters to the STING Database and by improving/e...

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Detalles Bibliográficos
Autores: NESHIC, G., BORRO, L. C., HIGA, R. H., KUSER, P. R., YAMAGISHI, M. E., FRANCO, E. H., KRAUCHENCO, J. N., FILETO, R., RIBEIRO, A. A., BEZERRA, G. B., VELLUDO, T. M., JIMENEZ, T. S., FURUKAWA, N., TESHIMA, H., KITAJIMA, K., BAVA, A., SARAI, A. TOGAWA, R. C., MANCINI, A. L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:Brasil
Institución:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
Repositorio:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Idioma:inglés
OAI Identifier:oai:www.alice.cnptia.embrapa.br:doc/186091
Acceso en línea:http://www.alice.cnptia.embrapa.br/alice/handle/doc/186091
Access Level:acceso abierto
Palabra clave:Diamond STING
STING
Protein structures
JavaProtein Dossier
Descripción
Sumario:Diamond STING is a new version of the STING suite of programs for a comprehensive analysis of a relationship between protein sequence, structure, function and stability. We have added a number of new functionalities by both providing more structure parameters to the STING Database and by improving/expanding the interface for enhanced data handling. The integration among the STING components has also been improved. A new key feature is the ability of the STING server to handle local files containing protein structures (either modeled or not yet deposited to the Protein Data Bank) so that they can be used by the principal STING components: JavaProtein Dossier (JPD) and STING Report. The current capabilities of the new STING version and a couple of biologically relevant applications are described here. We have provided an example where Diamond STING identifies the active site amino acids and folding essential amino acids (both previously determined by experiments) by filtering out all but those residues by selecting the numerical values/ranges for a set of corresponding parameters. This is the fundamental step toward a more interesting endeavor?the prediction of such residues. Diamond STING is freely accessible at http://sms.cbi.cnptia.embrapa.br and http://trantor.bioc.columbia.edu/SMS.

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