Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR

Acute electrolytic lesions of the commissural nucleus of the solitary tract (commNTS) reduce blood pressure (BP) in SHR but not in normotensive Wistar-Kyoto and Wistar rats and abolish the pressor response to intravenous injection of potassium cyanide. We investigated the chronic effect of commNTS l...

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Autores: Sato, Monica Akemi [UNIFESP], Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP], Menani, J. V., Lopes, Oswaldo Ubriaco [UNIFESP], Colombari, Eduardo [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/27422
Acceso en línea:http://dx.doi.org/10.1161/01.HYP.0000086523.51029.EC
http://repositorio.unifesp.br/handle/11600/27422
Access Level:acceso abierto
Palabra clave:baroreceptors
chemoreceptors
blood pressure
rats, spontaneously hypertensive
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spelling Recovery of high blood pressure after chronic lesions of the commissural NTS in SHRbaroreceptorschemoreceptorsblood pressurerats, spontaneously hypertensiveAcute electrolytic lesions of the commissural nucleus of the solitary tract (commNTS) reduce blood pressure (BP) in SHR but not in normotensive Wistar-Kyoto and Wistar rats and abolish the pressor response to intravenous injection of potassium cyanide. We investigated the chronic effect of commNTS lesions on mean arterial pressure (MAP), and on baroreceptor and chemoreceptor reflex responses in SHR. the contribution of the sympathetic nervous system and the hormones vasopressin and angiotensin II to maintenance of BP in lesioned SHR was also investigated. MAP fell to normotensive levels the day after lesioning the commNTS but returned to the hypertensive level 9 days later. the reflex tachycardia evoked by sodium nitroprusside remained attenuated for 10 days after commNTS lesions but became enhanced 30 days after commNTS lesions. the pressor component of the chemoreflex elicited by potassium cyanide remained blocked for 30 days after lesions. Vasopressin antagonist or ACE blocker did not change MAP in sham or commNTS-lesioned SHR. Ganglionic blockade with hexamethonium elicited similar reductions in MAP in sham and commNTS-lesioned SHR. Results demonstrated that commNTS lesions in SHR produce a transient fall in BP and a long-lasting inhibition of the pressor response of the chemoreflex. Therefore, the blockade of the pressor response to peripheral chemoreflex activation is not sufficient to chronically reduce MAP in SHR. in the chronic absence of the commNTS, other subnuclei of the NTS or other brain stem nuclei may reorganize to replace the function of commNTS neurons, restoring sympathetic activity and high BP in SHR.Universidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, São Paulo, BrazilFac Med ABC, Dept Physiol, Santo Andre, SP, BrazilUniv Estadual Paulista, Fac Odontol, Dept Physiol & Pathol, Araraquara, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Fac Med ABCUniv Estadual Paulista2016-01-24T12:34:04Z2016-01-24T12:34:04Z2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion713-718http://dx.doi.org/10.1161/01.HYP.0000086523.51029.ECHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 4, p. 713-718, 2003.10.1161/01.HYP.0000086523.51029.EC0194-911Xhttp://repositorio.unifesp.br/handle/11600/27422WOS:000185679000174ark:/48912/001300002pdpzengHypertensioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPSato, Monica Akemi [UNIFESP]Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]Menani, J. V.Lopes, Oswaldo Ubriaco [UNIFESP]Colombari, Eduardo [UNIFESP]2016-01-24T10:34:04Zoai:repositorio.unifesp.br:11600/27422Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T10:34:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
title Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
spellingShingle Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
Sato, Monica Akemi [UNIFESP]
baroreceptors
chemoreceptors
blood pressure
rats, spontaneously hypertensive
title_short Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
title_full Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
title_fullStr Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
title_full_unstemmed Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
title_sort Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR
dc.creator.none.fl_str_mv Sato, Monica Akemi [UNIFESP]
Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
Menani, J. V.
Lopes, Oswaldo Ubriaco [UNIFESP]
Colombari, Eduardo [UNIFESP]
author Sato, Monica Akemi [UNIFESP]
author_facet Sato, Monica Akemi [UNIFESP]
Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
Menani, J. V.
Lopes, Oswaldo Ubriaco [UNIFESP]
Colombari, Eduardo [UNIFESP]
author_role author
author2 Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
Menani, J. V.
Lopes, Oswaldo Ubriaco [UNIFESP]
Colombari, Eduardo [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
Univ Estadual Paulista
dc.subject.por.fl_str_mv baroreceptors
chemoreceptors
blood pressure
rats, spontaneously hypertensive
topic baroreceptors
chemoreceptors
blood pressure
rats, spontaneously hypertensive
description Acute electrolytic lesions of the commissural nucleus of the solitary tract (commNTS) reduce blood pressure (BP) in SHR but not in normotensive Wistar-Kyoto and Wistar rats and abolish the pressor response to intravenous injection of potassium cyanide. We investigated the chronic effect of commNTS lesions on mean arterial pressure (MAP), and on baroreceptor and chemoreceptor reflex responses in SHR. the contribution of the sympathetic nervous system and the hormones vasopressin and angiotensin II to maintenance of BP in lesioned SHR was also investigated. MAP fell to normotensive levels the day after lesioning the commNTS but returned to the hypertensive level 9 days later. the reflex tachycardia evoked by sodium nitroprusside remained attenuated for 10 days after commNTS lesions but became enhanced 30 days after commNTS lesions. the pressor component of the chemoreflex elicited by potassium cyanide remained blocked for 30 days after lesions. Vasopressin antagonist or ACE blocker did not change MAP in sham or commNTS-lesioned SHR. Ganglionic blockade with hexamethonium elicited similar reductions in MAP in sham and commNTS-lesioned SHR. Results demonstrated that commNTS lesions in SHR produce a transient fall in BP and a long-lasting inhibition of the pressor response of the chemoreflex. Therefore, the blockade of the pressor response to peripheral chemoreflex activation is not sufficient to chronically reduce MAP in SHR. in the chronic absence of the commNTS, other subnuclei of the NTS or other brain stem nuclei may reorganize to replace the function of commNTS neurons, restoring sympathetic activity and high BP in SHR.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
2016-01-24T12:34:04Z
2016-01-24T12:34:04Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1161/01.HYP.0000086523.51029.EC
Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 4, p. 713-718, 2003.
10.1161/01.HYP.0000086523.51029.EC
0194-911X
http://repositorio.unifesp.br/handle/11600/27422
WOS:000185679000174
dc.identifier.dark.fl_str_mv ark:/48912/001300002pdpz
url http://dx.doi.org/10.1161/01.HYP.0000086523.51029.EC
http://repositorio.unifesp.br/handle/11600/27422
identifier_str_mv Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 4, p. 713-718, 2003.
10.1161/01.HYP.0000086523.51029.EC
0194-911X
WOS:000185679000174
ark:/48912/001300002pdpz
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hypertension
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 713-718
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15.298079

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