Autoimmune diseases in the TH17 era
A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflamma...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/5083 |
| Acceso en línea: | http://dx.doi.org/10.1590/S0100-879X2009000600002 http://repositorio.unifesp.br/handle/11600/5083 |
| Access Level: | acceso abierto |
| Palabra clave: | Autoimmune diseases Cytokines TH17 cells IL-17 IL-22 IL-23 |
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Autoimmune diseases in the TH17 eraAutoimmune diseasesCytokinesTH17 cellsIL-17IL-22IL-23A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases, the fine balance between the proportion and degree of activation of the various T lymphocyte subsets can contribute to persistent undesirable inflammatory responses and tissue replacement by fibrosis. This review highlights the importance of TH17 cells in this process by providing an update on the biology of these cells and focusing on their biology and differentiation processes in the context of immune-mediated chronic inflammatory diseases.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Divisão de ReumatologiaUniversidade de São Paulo Instituto de Ciências Biomédicas Departamento de ImunologiaUniversidade de São Paulo Faculdade de Medicina Departamento de Clínica MédicaUniversidade Católica de Goiás Departamento de BiomedicinaUNIFESP, EPM, Divisão de ReumatologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Universidade Católica de Goiás Departamento de Biomedicina2015-06-14T13:39:15Z2015-06-14T13:39:15Z2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion476-486application/pdfhttp://dx.doi.org/10.1590/S0100-879X2009000600002Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 6, p. 476-486, 2009.10.1590/S0100-879X2009000600002S0100-879X2009000600002.pdf0100-879XS0100-879X2009000600002http://repositorio.unifesp.br/handle/11600/5083WOS:000266135800017ark:/48912/001300001vd9cengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPMesquita Júnior, Danilo [UNIFESP]Cruvinel, Wilson de Melo [UNIFESP]Câmara, Niels Olsen Saraiva [UNIFESP]Kállas, E.g.Andrade, Luiz Eduardo Coelho [UNIFESP]2024-08-05T23:30:01Zoai:repositorio.unifesp.br:11600/5083Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:30:01Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Autoimmune diseases in the TH17 era |
| title |
Autoimmune diseases in the TH17 era |
| spellingShingle |
Autoimmune diseases in the TH17 era Mesquita Júnior, Danilo [UNIFESP] Autoimmune diseases Cytokines TH17 cells IL-17 IL-22 IL-23 |
| title_short |
Autoimmune diseases in the TH17 era |
| title_full |
Autoimmune diseases in the TH17 era |
| title_fullStr |
Autoimmune diseases in the TH17 era |
| title_full_unstemmed |
Autoimmune diseases in the TH17 era |
| title_sort |
Autoimmune diseases in the TH17 era |
| dc.creator.none.fl_str_mv |
Mesquita Júnior, Danilo [UNIFESP] Cruvinel, Wilson de Melo [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] Kállas, E.g. Andrade, Luiz Eduardo Coelho [UNIFESP] |
| author |
Mesquita Júnior, Danilo [UNIFESP] |
| author_facet |
Mesquita Júnior, Danilo [UNIFESP] Cruvinel, Wilson de Melo [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] Kállas, E.g. Andrade, Luiz Eduardo Coelho [UNIFESP] |
| author_role |
author |
| author2 |
Cruvinel, Wilson de Melo [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] Kállas, E.g. Andrade, Luiz Eduardo Coelho [UNIFESP] |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Universidade Católica de Goiás Departamento de Biomedicina |
| dc.subject.por.fl_str_mv |
Autoimmune diseases Cytokines TH17 cells IL-17 IL-22 IL-23 |
| topic |
Autoimmune diseases Cytokines TH17 cells IL-17 IL-22 IL-23 |
| description |
A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases, the fine balance between the proportion and degree of activation of the various T lymphocyte subsets can contribute to persistent undesirable inflammatory responses and tissue replacement by fibrosis. This review highlights the importance of TH17 cells in this process by providing an update on the biology of these cells and focusing on their biology and differentiation processes in the context of immune-mediated chronic inflammatory diseases. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-06-01 2015-06-14T13:39:15Z 2015-06-14T13:39:15Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2009000600002 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 6, p. 476-486, 2009. 10.1590/S0100-879X2009000600002 S0100-879X2009000600002.pdf 0100-879X S0100-879X2009000600002 http://repositorio.unifesp.br/handle/11600/5083 WOS:000266135800017 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001vd9c |
| url |
http://dx.doi.org/10.1590/S0100-879X2009000600002 http://repositorio.unifesp.br/handle/11600/5083 |
| identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 6, p. 476-486, 2009. 10.1590/S0100-879X2009000600002 S0100-879X2009000600002.pdf 0100-879X S0100-879X2009000600002 WOS:000266135800017 ark:/48912/001300001vd9c |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
476-486 application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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15.300719 |