The neuroendocrine role in the control of hunger and satiety and its relationship with obesity

Obesity is a chronic disorder of multifactorial origin (neuroendocrine, psychic, intestinal and genetic factors) that results from a metabolic-energetic imbalance, whereby a long-term excess of energy intake over expenditure leads to accumulation in the form of fat. The control of the energy balance...

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Detalles Bibliográficos
Autores: Silva, Saray Sallin da, Silva, Shara Hozana, Aguiar, Géssica Adorno, Batista, Stefane Oliveira, Santos , Ana Clara Marinho, Bandeira, Fernanda Láuria Chaves, Alves, Maryana Teixeira, Silva, Áthila Gabriele Ferreira da, Sousa, Vanessa Alves de, Rodrigues, Cicera Natália da Silva, Silva, Nibsyan Cristina da, Souza, Letícia Aparecida de, Oliveira , Thaysa Renata Jorge, Cardoso, Bianca Silva, Gonçalves, Josyane Borges da Silva
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Institución:Universidade Federal de Itajubá (UNIFEI)
Repositorio:Research, Society and Development
Idioma:portugués
OAI Identifier:oai:ojs.pkp.sfu.ca:article/25621
Acceso en línea:https://rsdjournal.org/index.php/rsd/article/view/25621
Access Level:acceso abierto
Palabra clave:Obesity
Hunger
Satiety.
Obesidad
Hambriento
Saciedad.
Obesidade
Fome
Saciedade.
Descripción
Sumario:Obesity is a chronic disorder of multifactorial origin (neuroendocrine, psychic, intestinal and genetic factors) that results from a metabolic-energetic imbalance, whereby a long-term excess of energy intake over expenditure leads to accumulation in the form of fat. The control of the energy balance is carried out by the central nervous system by means of necessary neuroendocrines, in which peripheral circulating hormones, such as leptin and insulin, signal specialized neurons of the hypothalamus over the body's fat stores and induce adequate responses for the maintenance of stocks god stability. Thus, the positive energy balance for a long period, determined by macronutrient intake, energy expenditure and thermogenesis, will result in body weight gain in the form of fat, while the negative energy balance will result in no opposite effect. In this systematic review of works published between 2008 and 2021, neuroendocrine mechanisms that control hunger and satiety, and their relationship with obesity, will be discussed. Thus evidencing that this regulation is carried out by a complex mechanism that needs to be very well understood in order to treat or even prevent obesity.

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