Doença de Crohn: aspectos do tratamento na atualidade
Objective: To uncover the most recent scientific production regarding the therapy used in the treatment of Crohn’s disease (CD). Methods: This is an integrative review of the literature which the search was carried out in the publications of the Biblioteca Virtual de Saúde (BVS). The MEDLINE databas...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | Brasil |
| Recursos: | Universidade Federal do Ceará (UFC) |
| Repositorio: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufc.br:riufc/48300 |
| Acesso em linha: | http://www.repositorio.ufc.br/handle/riufc/48300 |
| Access Level: | acceso abierto |
| Palavra-chave: | Doença de Crohn Tratamento Farmacológico Gastroenterologia |
| Resumo: | Objective: To uncover the most recent scientific production regarding the therapy used in the treatment of Crohn’s disease (CD). Methods: This is an integrative review of the literature which the search was carried out in the publications of the Biblioteca Virtual de Saúde (BVS). The MEDLINE database was used through studies available for viewing in gastroenterology journals published between 2012 and 2016, totaling 33 articles. Results: Among the analyzed articles, 81,8% addressed pharmacological therapy, which consists mainly of steroids and immunosuppressants and, in nonresponsive patients, biological compounds such as anti-TNF alpha. Adalimumab had more adverse effects than infliximab. Thiopurines have been associated with hepatic impairment. Total parenteral nutrition has shown to be important and is recommended for patients with moderate to severe CD and exclusive enteral nutrition for first-line treatment in children with CD. There has been a decreasing need for surgery after the use of immunomodulators. Fecal microbiota transplantation has been reported as an alternative therapy in cases of complicated refractory CD. Conclusions: The prevalence of studies on pharmacological therapy and the need for new studies on the therapeutic options of CD, especially with regard to non-pharmacological therapy, were observed. |
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