Anti-mycobacterium tuberculosis and cytotoxicity activities of ruthenium(II)/Bipyridine/Diphosphine/Pyrimidine-2-thiolate complexes: The role of the non-coordinated n-atom
The [Ru(Spym)(bipy)(P-P)]PF6, [Spym = pyrimidine-2-thiolate anion; P-P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1'-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/172549 |
| Acceso en línea: | http://dx.doi.org/10.5935/0103-5053.20150237 http://hdl.handle.net/11449/172549 |
| Access Level: | acceso abierto |
| Palabra clave: | Cytotoxity Diphosphine ligand Pyrimidine-2-thiolate Ruthenium complexes Tuberculosis |
| Sumario: | The [Ru(Spym)(bipy)(P-P)]PF6, [Spym = pyrimidine-2-thiolate anion; P-P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1'-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA. |
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