Postoperative rhabdomyolysis due to neuroleptic malignant syndrome associated with droperidol and metoclopramide
Neuroleptic malignant syndrome (NMS) is a complication of neuroleptics that can rarely occur per operatively. A female patient, 28 years old, ASA I, was admitted for bilateral mammoplasty with breast implant. During the procedure, under sedation and thoracic epidural, she received droperidol and met...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/70718 |
| Acceso en línea: | https://www.termedia.pl/Postoperative-rhabdomyolysis-due-to-neuroleptic-malignant-syndrome-associated-with-droperidol-and-metoclopramide,118,51786,1,1.html https://repositorio.unifesp.br/handle/11600/70718 https://doi.org/10.5114/ait.2023.132910 |
| Access Level: | acceso abierto |
| Palabra clave: | Neuroleptic malignant syndrome Anaesthesia Droperidol Metoclopramide |
| Sumario: | Neuroleptic malignant syndrome (NMS) is a complication of neuroleptics that can rarely occur per operatively. A female patient, 28 years old, ASA I, was admitted for bilateral mammoplasty with breast implant. During the procedure, under sedation and thoracic epidural, she received droperidol and metoclopramide. After two hours, she evolved with myalgia, tachycardia, tachypnea, hyperthermia, and increased creatine kinase (CK) levels (9,702 IU/L). After supportive therapy, there was a complete improvement. A further extensive investigation with physical/neurological examination, baseline serum CK level, and electroneuromyography was normal. Molecular study for myopathies did not detect any pathogenic variant and the in vitro muscle contracture test for malignant hyperthermia was negative. Diagnosis of exclusion of NMS was performed. The anaesthesiologist must recognize NMS manifestations, allowing early treatment. |
|---|