Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis
Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conserva...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/72787 |
| Acceso en línea: | http://dx.doi.org/10.1186/1477-5751-10-14 http://hdl.handle.net/11449/72787 |
| Access Level: | acceso abierto |
| Palabra clave: | chemokine CXCR1 cytokine genetic polymorphism periodontal disease chemokine receptor CXCR1 adult chronic periodontitis disease predisposition female gene frequency genetic variability genotype human major clinical study male single nucleotide polymorphism genetic predisposition genetics haplotype middle aged Adult Chronic Periodontitis Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Receptors, Interleukin-8A |
| Sumario: | Background: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd. |
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