Risk factors associated pneumonia in post operative early liver transplant

Purpose: To identify the main risk factors related to pneumonia in early pre-liver transplant surgery. Methods: A control case study performed from June to December of 2014 with patients submitted to liver transplant in a medical teaching hospital in Fortaleza, state of Ceará. It was included in the...

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Autores: Bravo, Lorena Guedes, Coelho, Gustavo Rêgo, Campos, Maria Flávia Amâncio, Girão, Evelyne Santana, Garcia, José Huygens Parente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Brasil
Institución:Associação Brasileira de Transplante de Órgãos (ABTO)
Repositorio:Brazilian Journal of Transplantation
Idioma:portugués
OAI Identifier:oai:ojs3.emnuvens.com.br:article/120
Acceso en línea:https://bjt.emnuvens.com.br/revista/article/view/120
Access Level:acceso abierto
Palabra clave:Unidade de Terapia Intensiva
Transplante de Fígado
Diafragma
Respiração Artificial
Extubação
Risk Factors
Liver Transplantation
Pneumonia
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network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Risk factors associated pneumonia in post operative early liver transplant
FATORES DE RISCO RELACIONADOS À PNEUMONIA NO PÓS-OPERATÓRIO PRECOCE DE TRANSPLANTE DE FÍGADO
title Risk factors associated pneumonia in post operative early liver transplant
spellingShingle Risk factors associated pneumonia in post operative early liver transplant
Bravo, Lorena Guedes
Unidade de Terapia Intensiva
Transplante de Fígado
Diafragma
Respiração Artificial
Extubação
Risk Factors
Liver Transplantation
Pneumonia
title_short Risk factors associated pneumonia in post operative early liver transplant
title_full Risk factors associated pneumonia in post operative early liver transplant
title_fullStr Risk factors associated pneumonia in post operative early liver transplant
title_full_unstemmed Risk factors associated pneumonia in post operative early liver transplant
title_sort Risk factors associated pneumonia in post operative early liver transplant
dc.creator.none.fl_str_mv Bravo, Lorena Guedes
Coelho, Gustavo Rêgo
Campos, Maria Flávia Amâncio
Girão, Evelyne Santana
Garcia, José Huygens Parente
author Bravo, Lorena Guedes
author_facet Bravo, Lorena Guedes
Coelho, Gustavo Rêgo
Campos, Maria Flávia Amâncio
Girão, Evelyne Santana
Garcia, José Huygens Parente
author_role author
author2 Coelho, Gustavo Rêgo
Campos, Maria Flávia Amâncio
Girão, Evelyne Santana
Garcia, José Huygens Parente
author2_role author
author
author
author
dc.subject.por.fl_str_mv Unidade de Terapia Intensiva
Transplante de Fígado
Diafragma
Respiração Artificial
Extubação
Risk Factors
Liver Transplantation
Pneumonia
topic Unidade de Terapia Intensiva
Transplante de Fígado
Diafragma
Respiração Artificial
Extubação
Risk Factors
Liver Transplantation
Pneumonia
description Purpose: To identify the main risk factors related to pneumonia in early pre-liver transplant surgery. Methods: A control case study performed from June to December of 2014 with patients submitted to liver transplant in a medical teaching hospital in Fortaleza, state of Ceará. It was included in the study patients of both genders submitted to liver transplant, and those presenting insufficient data in their medical records which would damage the analysis of data, those who died until the 5th post-surgery day, and those who were submitted to re-transplant due to primary dysfunction of the graft were excluded. The data collection was performed from June to December of 2014 by prospective analysis of the records from every patient submitted to liver transplant during that period. The records were analyzed in the pre, trans-, and post-surgery periods up to their hospital discharge. Results: The sampling was composed by 52 patients being 69.2% male with average age of 55 years ( 12.5). Different etiologies were found from which the most predominant were viral hepatitis (51.9%) and alcoholic cirrhosis (21.1%). Participants in the sampling presented an average MELD score of 22 ( 4.8). The potential risk factors to develop early pneumonia in the liver post-transplantation by bivariate analysis include age (p= 0.09), pre-surgery MELD (p= 0.22), pre-hospitalization to the surgery (p= 0.09), time of cold ischemia (p=0.22), and time of mechanical ventilation (p= 0.08). In the multivariate analysis, the independent risk factors were higher time in intensive care unit (p=0.002), need for reintubation (p= 0.002), and use of a prophylactic antibiotic other than Ampicilin + Sulbactam (routine prophylactic antibiotic in the service) (p= 0.02). Conclusion: Pneumonia is a frequent pulmonary complication with a high mortality rate in the early liver post-transplant period. Such complication can be associated with several pre-, trans- and post-surgery factors.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://bjt.emnuvens.com.br/revista/article/view/120
10.53855/bjt.v18i1.120
url https://bjt.emnuvens.com.br/revista/article/view/120
identifier_str_mv 10.53855/bjt.v18i1.120
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://bjt.emnuvens.com.br/revista/article/view/120/109
dc.rights.driver.fl_str_mv Copyright (c) 2021 Brazilian Journal of Transplantation
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Brazilian Journal of Transplantation
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Transplante de Órgãos (ABTO)
publisher.none.fl_str_mv Associação Brasileira de Transplante de Órgãos (ABTO)
dc.source.none.fl_str_mv Brazilian Journal of Transplantation; Vol. 18 No. 1 (2015); 6-11
Brazilian Journal of Transplantation; v. 18 n. 1 (2015); 6-11
2764-1589
reponame:Brazilian Journal of Transplantation
instname:Associação Brasileira de Transplante de Órgãos (ABTO)
instacron:ABTO
instname_str Associação Brasileira de Transplante de Órgãos (ABTO)
instacron_str ABTO
institution ABTO
reponame_str Brazilian Journal of Transplantation
collection Brazilian Journal of Transplantation
repository.name.fl_str_mv Brazilian Journal of Transplantation - Associação Brasileira de Transplante de Órgãos (ABTO)
repository.mail.fl_str_mv bjt@abto.org.br
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spelling Risk factors associated pneumonia in post operative early liver transplantFATORES DE RISCO RELACIONADOS À PNEUMONIA NO PÓS-OPERATÓRIO PRECOCE DE TRANSPLANTE DE FÍGADOUnidade de Terapia IntensivaTransplante de FígadoDiafragmaRespiração ArtificialExtubaçãoRisk FactorsLiver TransplantationPneumoniaPurpose: To identify the main risk factors related to pneumonia in early pre-liver transplant surgery. Methods: A control case study performed from June to December of 2014 with patients submitted to liver transplant in a medical teaching hospital in Fortaleza, state of Ceará. It was included in the study patients of both genders submitted to liver transplant, and those presenting insufficient data in their medical records which would damage the analysis of data, those who died until the 5th post-surgery day, and those who were submitted to re-transplant due to primary dysfunction of the graft were excluded. The data collection was performed from June to December of 2014 by prospective analysis of the records from every patient submitted to liver transplant during that period. The records were analyzed in the pre, trans-, and post-surgery periods up to their hospital discharge. Results: The sampling was composed by 52 patients being 69.2% male with average age of 55 years ( 12.5). Different etiologies were found from which the most predominant were viral hepatitis (51.9%) and alcoholic cirrhosis (21.1%). Participants in the sampling presented an average MELD score of 22 ( 4.8). The potential risk factors to develop early pneumonia in the liver post-transplantation by bivariate analysis include age (p= 0.09), pre-surgery MELD (p= 0.22), pre-hospitalization to the surgery (p= 0.09), time of cold ischemia (p=0.22), and time of mechanical ventilation (p= 0.08). In the multivariate analysis, the independent risk factors were higher time in intensive care unit (p=0.002), need for reintubation (p= 0.002), and use of a prophylactic antibiotic other than Ampicilin + Sulbactam (routine prophylactic antibiotic in the service) (p= 0.02). Conclusion: Pneumonia is a frequent pulmonary complication with a high mortality rate in the early liver post-transplant period. Such complication can be associated with several pre-, trans- and post-surgery factors.Objetivo: Identificar os principais fatores de risco relacionados   à pneumonia no pós-operatório precoce de transplante de fígado. Métodos: Foi realizado um estudo de caso controle no período de junho a dezembro de 2014, com pacientes submetidos a transplante hepático nesse período, em um hospital universitário de Fortaleza/CE. Foram incluídos no estudo, pacientes de ambos os gêneros que foram submetidos a transplante hepático, e excluídos aqueles que apresentavam dados insuficientes no prontuário, prejudicando a análise dos dados, os que evoluíram para óbito até ao 5o dia pós-operaório e os que foram submetidos a retransplante por disfunção primária do enxerto. A coleta de dados ocorreu de junho a dezembro de 2014, através da análise prospectiva dos prontuários de todos os pacientes submetidos a transplante hepático nesse período. Os prontuários foram analisados no período pré, trans e pós-operatório até a alta hospitalar. Resultados: A amostra foi composta por 52 pacientes, sendo 69,2% do gênero masculino, com idade média de 55 (+12,5) anos. Foram encontradas diferentes etiologias, das quais as de maior prevalência foram as hepatites virais (51,9%) e a cirrose alcoólica (21,1%). Os participantes da amostra apresentaram escore MELD médio 22 (+4,8). Os potenciais fatores de risco para o desenvolvimento de pneumonia precoce no pós-transplante de fígado através da análise bivariada incluem idade (p= 0,09), MELD pré-operatório (p= 0,22), internamento prévio à cirurgia (p= 0,09), tempo de isquemia fria (p=0,22) e tempo de ventilação mecânica (p= 0,08). Na análise multivariada, os fatores de risco independentes foram: maior tempo em unidade de terapia intensiva (p=0,002), necessidade do procedimento de reintubação (p= 0,002) e uso de antibiótico profilítico diferente de Ampicilina + Sulbactam (antibiótico profilítico de rotina do serviço) (p= 0,02). Conclusão: A pneumonia é uma complicação pulmonar frequente, com alta taxa de mortalidade no pós-operatório precoce de transplante hepático. Essa complicação pode ser associada a vários fatores pré, trans e pós-operatório.Associação Brasileira de Transplante de Órgãos (ABTO)2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjt.emnuvens.com.br/revista/article/view/12010.53855/bjt.v18i1.120Brazilian Journal of Transplantation; Vol. 18 No. 1 (2015); 6-11Brazilian Journal of Transplantation; v. 18 n. 1 (2015); 6-112764-1589reponame:Brazilian Journal of Transplantationinstname:Associação Brasileira de Transplante de Órgãos (ABTO)instacron:ABTOporhttps://bjt.emnuvens.com.br/revista/article/view/120/109Copyright (c) 2021 Brazilian Journal of Transplantationinfo:eu-repo/semantics/openAccessBravo, Lorena GuedesCoelho, Gustavo RêgoCampos, Maria Flávia AmâncioGirão, Evelyne SantanaGarcia, José Huygens Parente2021-09-28T14:34:48Zoai:ojs3.emnuvens.com.br:article/120Revistahttps://bjt.emnuvens.com.br/revistaONGhttps://bjt.emnuvens.com.br/revista/oaibjt@abto.org.brhttps://doi.org/10.53855/2764-15892764-1589opendoar:2021-09-28T14:34:48Brazilian Journal of Transplantation - Associação Brasileira de Transplante de Órgãos (ABTO)false
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