Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample

Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements...

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Detalhes bibliográficos
Autores: Mazzotti, Diego Robles [UNIFESP], Guindalini, Camila [UNIFESP], Pellegrino, Renata [UNIFESP], Barrueco, Karina Fonseca [UNIFESP], Santos-Silva, Rogerio [UNIFESP], Bittencourt, Lia Rita Azeredo [UNIFESP], Tufik, Sergio [UNIFESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Recursos:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/45611
Acesso em linha:https://doi.org/10.1093/sleep/34.3.399
https://repositorio.unifesp.br/handle/11600/45611
Access Level:acceso abierto
Palavra-chave:Sleep
Adenosine deaminase
Caffeine intake
Polymorphism
Sleep efficiency
Descrição
Resumo:Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.

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