Association between the BCR-ABL gene transcripts and the laboratory hematological profile
Objective: This study describes the hematological parameters associated with the BCR-ABL gene transcripts in patients with chronic myeloid leukemia (CML). Methods: We reviewed the results of 100 detectable patients for one of the BCR-ABL gene transcripts. The eligibility criteria were based on the p...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Brasil |
| Institución: | Hospital de Clínicas de Itajubá |
| Repositorio: | Revista Ciências em Saúde |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.portalrcs.hcitajuba.org.br:article/1281 |
| Acceso en línea: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1281 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic Myeloid Leukemia BCR ABL gene Hematology Leucemia Mieloide Crônica gene BCR ABL Hematologia |
| Sumario: | Objective: This study describes the hematological parameters associated with the BCR-ABL gene transcripts in patients with chronic myeloid leukemia (CML). Methods: We reviewed the results of 100 detectable patients for one of the BCR-ABL gene transcripts. The eligibility criteria were based on the presence of one of the leukemic transcripts (b2a2, b3a2, and b2a2/b3a2) and complete epidemiological and hematological data. The data were obtained from the LabMaster computerized system. The Kruskal-Wallis test was used to compare the medians of the quantitative variables between the transcripts of the BCR-ABL gene and the chi-square test to compare the qualitative ones, adopting the p-value with a level of significance less than or equal to 0.05. Results: Forty-five patients (45%) presented the b2a2 transcript, 24 (24%) the b3a2 transcript and 31 (31%) a b2a2/b3a2 coexpression. Individuals who expressed the b3a2 transcript had higher leukocyte counts and platelet levels, but we found no differences compared with individuals who expressed the other transcript. Conclusion: In this study, the BCR-ABL gene transcripts did not influence the hematological parameters of patients with CML. |
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