Hemodialysis improves endothelial venous function in end-stage renal disease

The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 month...

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Autores: Silva, Antônio Marcos Vargas da, Signori, Luis Ulisses, Plentz, Rodrigo Della Méa, Barros, Elvino José Guardão, Belló-Klein, Adriane, Schaan, Beatriz D'Agord, Irigoyen, Maria Claudia Costa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/21239
Acceso en línea:http://hdl.handle.net/10183/21239
Access Level:acceso abierto
Palabra clave:Diálise renal
Endotélio vascular
Estresse oxidativo
End-stage renal disease
Hemodialysis
Oxidative stress
Vascular endothelium
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spelling 2010-04-24T04:15:54Z20080100-879Xhttp://hdl.handle.net/10183/21239000715733The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential - TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP (402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/μL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 41, no. 6 (June 2008), p. 482-488Diálise renalEndotélio vascularEstresse oxidativoEnd-stage renal diseaseHemodialysisOxidative stressVascular endotheliumHemodialysis improves endothelial venous function in end-stage renal diseaseinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSSilva, Antônio Marcos Vargas daSignori, Luis UlissesPlentz, Rodrigo Della MéaBarros, Elvino José GuardãoBelló-Klein, AdrianeSchaan, Beatriz D'AgordIrigoyen, Maria Claudia CostaORIGINAL000715733.pdf000715733.pdfTexto completo (inglês)application/pdf480221http://www.lume.ufrgs.br/bitstream/10183/21239/1/000715733.pdfa5949898a447cf14663e2c327b771431MD51TEXT000715733.pdf.txt000715733.pdf.txtExtracted Texttext/plain30997http://www.lume.ufrgs.br/bitstream/10183/21239/2/000715733.pdf.txtfba26fce4f9dbff26f394cffb8f6b5a0MD52THUMBNAIL000715733.pdf.jpg000715733.pdf.jpgGenerated Thumbnailimage/jpeg2092http://www.lume.ufrgs.br/bitstream/10183/21239/3/000715733.pdf.jpg7b4fa4c63a33eacf42fc6b6289d78d68MD5310183/212392025-01-12 07:39:44.427059oai:www.lume.ufrgs.br:10183/21239Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2025-01-12T09:39:44Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Hemodialysis improves endothelial venous function in end-stage renal disease
title Hemodialysis improves endothelial venous function in end-stage renal disease
spellingShingle Hemodialysis improves endothelial venous function in end-stage renal disease
Silva, Antônio Marcos Vargas da
Diálise renal
Endotélio vascular
Estresse oxidativo
End-stage renal disease
Hemodialysis
Oxidative stress
Vascular endothelium
title_short Hemodialysis improves endothelial venous function in end-stage renal disease
title_full Hemodialysis improves endothelial venous function in end-stage renal disease
title_fullStr Hemodialysis improves endothelial venous function in end-stage renal disease
title_full_unstemmed Hemodialysis improves endothelial venous function in end-stage renal disease
title_sort Hemodialysis improves endothelial venous function in end-stage renal disease
dc.creator.none.fl_str_mv Silva, Antônio Marcos Vargas da
Signori, Luis Ulisses
Plentz, Rodrigo Della Méa
Barros, Elvino José Guardão
Belló-Klein, Adriane
Schaan, Beatriz D'Agord
Irigoyen, Maria Claudia Costa
author Silva, Antônio Marcos Vargas da
author_facet Silva, Antônio Marcos Vargas da
Signori, Luis Ulisses
Plentz, Rodrigo Della Méa
Barros, Elvino José Guardão
Belló-Klein, Adriane
Schaan, Beatriz D'Agord
Irigoyen, Maria Claudia Costa
author_role author
author2 Signori, Luis Ulisses
Plentz, Rodrigo Della Méa
Barros, Elvino José Guardão
Belló-Klein, Adriane
Schaan, Beatriz D'Agord
Irigoyen, Maria Claudia Costa
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Diálise renal
Endotélio vascular
Estresse oxidativo
topic Diálise renal
Endotélio vascular
Estresse oxidativo
End-stage renal disease
Hemodialysis
Oxidative stress
Vascular endothelium
dc.subject.eng.fl_str_mv End-stage renal disease
Hemodialysis
Oxidative stress
Vascular endothelium
description The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential - TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP (402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/μL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect.
publishDate 2008
dc.date.issued.fl_str_mv 2008
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 41, no. 6 (June 2008), p. 482-488
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