DNA and histone methylation in gastric carcinogenesis
Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/35986 |
| Acceso en línea: | http://dx.doi.org/10.3748/wjg.v19.i8.1182 http://repositorio.unifesp.br/handle/11600/35986 |
| Access Level: | acceso abierto |
| Palabra clave: | Epigenetic DNA methylation Histone methylation Gastric cancer Gastric carcinogenesis |
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DNA and histone methylation in gastric carcinogenesisEpigeneticDNA methylationHistone methylationGastric cancerGastric carcinogenesisEpigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. (C) 2013 Baishideng. All rights reserved.Universidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, BrazilFed Univ Para, Lab Human Cytogenet, Inst Biol Sci, BR-66075110 Belem, Para, BrazilUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP: 2009/07145-9FAPESP: 2010/11174-1Baishideng Publishing Group IncUniversidade Federal de São Paulo (UNIFESP)Fed Univ Para2016-01-24T14:31:16Z2016-01-24T14:31:16Z2013-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1182-1192http://dx.doi.org/10.3748/wjg.v19.i8.1182World Journal of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 19, n. 8, p. 1182-1192, 2013.10.3748/wjg.v19.i8.11821007-9327http://repositorio.unifesp.br/handle/11600/35986WOS:000315521700005ark:/48912/001300001cm3fengWorld Journal of Gastroenterologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPCalcagno, Danielle Queiroz [UNIFESP]Gigek, Carolina Oliveira [UNIFESP]Chen, Elizabeth Suchi [UNIFESP]Burbano, Rommel RodriguezCardoso Smith, Marilia de Arruda [UNIFESP]2023-03-24T14:24:05Zoai:repositorio.unifesp.br:11600/35986Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-24T14:24:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
DNA and histone methylation in gastric carcinogenesis |
| title |
DNA and histone methylation in gastric carcinogenesis |
| spellingShingle |
DNA and histone methylation in gastric carcinogenesis Calcagno, Danielle Queiroz [UNIFESP] Epigenetic DNA methylation Histone methylation Gastric cancer Gastric carcinogenesis |
| title_short |
DNA and histone methylation in gastric carcinogenesis |
| title_full |
DNA and histone methylation in gastric carcinogenesis |
| title_fullStr |
DNA and histone methylation in gastric carcinogenesis |
| title_full_unstemmed |
DNA and histone methylation in gastric carcinogenesis |
| title_sort |
DNA and histone methylation in gastric carcinogenesis |
| dc.creator.none.fl_str_mv |
Calcagno, Danielle Queiroz [UNIFESP] Gigek, Carolina Oliveira [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Burbano, Rommel Rodriguez Cardoso Smith, Marilia de Arruda [UNIFESP] |
| author |
Calcagno, Danielle Queiroz [UNIFESP] |
| author_facet |
Calcagno, Danielle Queiroz [UNIFESP] Gigek, Carolina Oliveira [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Burbano, Rommel Rodriguez Cardoso Smith, Marilia de Arruda [UNIFESP] |
| author_role |
author |
| author2 |
Gigek, Carolina Oliveira [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Burbano, Rommel Rodriguez Cardoso Smith, Marilia de Arruda [UNIFESP] |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Fed Univ Para |
| dc.subject.por.fl_str_mv |
Epigenetic DNA methylation Histone methylation Gastric cancer Gastric carcinogenesis |
| topic |
Epigenetic DNA methylation Histone methylation Gastric cancer Gastric carcinogenesis |
| description |
Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. (C) 2013 Baishideng. All rights reserved. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-02-28 2016-01-24T14:31:16Z 2016-01-24T14:31:16Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3748/wjg.v19.i8.1182 World Journal of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 19, n. 8, p. 1182-1192, 2013. 10.3748/wjg.v19.i8.1182 1007-9327 http://repositorio.unifesp.br/handle/11600/35986 WOS:000315521700005 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001cm3f |
| url |
http://dx.doi.org/10.3748/wjg.v19.i8.1182 http://repositorio.unifesp.br/handle/11600/35986 |
| identifier_str_mv |
World Journal of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 19, n. 8, p. 1182-1192, 2013. 10.3748/wjg.v19.i8.1182 1007-9327 WOS:000315521700005 ark:/48912/001300001cm3f |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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World Journal of Gastroenterology |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
1182-1192 |
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Baishideng Publishing Group Inc |
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Baishideng Publishing Group Inc |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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15,300719 |