Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors
Background. Coronary artery calcification is a common feature of atherosclerosis, occurring in 90% of angiographically significant lesions. There is recent evidence that coronary artery calcification is frequent in hemodialysis patients and it has been suggested that this increased incidence may be...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/28204 |
| Acceso en línea: | http://dx.doi.org/10.1111/j.1523-1755.2005.00239.x http://repositorio.unifesp.br/handle/11600/28204 |
| Access Level: | acceso abierto |
| Palabra clave: | coronary calcification atherosclerosis renal failure bone inflammation osteoprotegerin |
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Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factorscoronary calcificationatherosclerosisrenal failureboneinflammationosteoprotegerinBackground. Coronary artery calcification is a common feature of atherosclerosis, occurring in 90% of angiographically significant lesions. There is recent evidence that coronary artery calcification is frequent in hemodialysis patients and it has been suggested that this increased incidence may be associated to uremia-related factors. the development and progression of coronary artery calcification is similar to osteogenesis. the aim of this study was to evaluate the relationship between coronary artery calcification, uremia-related factors, and bone histomorphometry in hemodialysis patients.Methods. A total of 101 hemodialysis patients were assessed for biochemical markers of inflammation, oxidative stress, and bone metabolism. Subsequently, they were submitted to multislice coronary tomography (MSCT) and transiliac bone biopsy.Results. the median calcium score was 116.2 (range 0 to 5547). Fifty-two percent of the patients showed moderate and severe coronary artery calcification, 20% had calcium scores greater than 1000. in univariate analysis, age (r= 0.57, P < 0.000001), osteoprotegerin (OPG) (r= 0.44, P= 0.00002), and body mass index (BMI) (r= 0.24, P= 0.01) correlated positively with calcium score. Bone trabecular volume and trabecular thickness correlated negatively with calcium score (r=-0.24, P= 0.02; r=-0.22, P= 0.03). There was a correlation of borderline significance between calcium score and C-reactive protein (CRP) (r= 0.18, P= 0.062). the multiple linear regression analysis identified OPG as the only variable independently associated with coronary artery calcification.Conclusion. Coronary artery calcification is highly prevalent in the hemodialysis population and is associated with older age, higher BMI, inflammation and reduced trabecular bone volume. Higher OPG is independently associated with coronary artery calcification and may represent an incomplete self-defensive response to the progression of atherosclerosis in hemodialysis patients.Universidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilUniv São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilGenzyme Corp, Cambridge, MA USAUniversidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilWeb of ScienceBlackwell Publishing IncUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Genzyme Corp2016-01-24T12:37:44Z2016-01-24T12:37:44Z2005-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1576-1582http://dx.doi.org/10.1111/j.1523-1755.2005.00239.xKidney International. Malden: Blackwell Publishing Inc, v. 67, n. 4, p. 1576-1582, 2005.10.1111/j.1523-1755.2005.00239.x0085-2538http://repositorio.unifesp.br/handle/11600/28204WOS:000227596500041ark:/48912/001300001zrkvengKidney Internationalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPBarreto, Daniela VeitBarreto, Fellype CarvalhoCarvalho, Aluízio Barbosa de [UNIFESP]Cuppari, Lillian [UNIFESP]Cendoroglo Neto, Miguel [UNIFESP]Draibe, Sergio Antonio [UNIFESP]Moyses, Rosa Marie AfonsoNeves, Kátia RodriguesJorgetti, VandaBlair, AndrewGuiberteau, RobertCanziani, Maria Eugênia Fernandes [UNIFESP]2023-05-18T14:25:09Zoai:repositorio.unifesp.br:11600/28204Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-05-18T14:25:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| title |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| spellingShingle |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors Barreto, Daniela Veit coronary calcification atherosclerosis renal failure bone inflammation osteoprotegerin |
| title_short |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| title_full |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| title_fullStr |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| title_full_unstemmed |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| title_sort |
Coronary calcification in hemodialysis patients: the contribution of traditional and uremia-related risk factors |
| dc.creator.none.fl_str_mv |
Barreto, Daniela Veit Barreto, Fellype Carvalho Carvalho, Aluízio Barbosa de [UNIFESP] Cuppari, Lillian [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Moyses, Rosa Marie Afonso Neves, Kátia Rodrigues Jorgetti, Vanda Blair, Andrew Guiberteau, Robert Canziani, Maria Eugênia Fernandes [UNIFESP] |
| author |
Barreto, Daniela Veit |
| author_facet |
Barreto, Daniela Veit Barreto, Fellype Carvalho Carvalho, Aluízio Barbosa de [UNIFESP] Cuppari, Lillian [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Moyses, Rosa Marie Afonso Neves, Kátia Rodrigues Jorgetti, Vanda Blair, Andrew Guiberteau, Robert Canziani, Maria Eugênia Fernandes [UNIFESP] |
| author_role |
author |
| author2 |
Barreto, Fellype Carvalho Carvalho, Aluízio Barbosa de [UNIFESP] Cuppari, Lillian [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Moyses, Rosa Marie Afonso Neves, Kátia Rodrigues Jorgetti, Vanda Blair, Andrew Guiberteau, Robert Canziani, Maria Eugênia Fernandes [UNIFESP] |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Genzyme Corp |
| dc.subject.por.fl_str_mv |
coronary calcification atherosclerosis renal failure bone inflammation osteoprotegerin |
| topic |
coronary calcification atherosclerosis renal failure bone inflammation osteoprotegerin |
| description |
Background. Coronary artery calcification is a common feature of atherosclerosis, occurring in 90% of angiographically significant lesions. There is recent evidence that coronary artery calcification is frequent in hemodialysis patients and it has been suggested that this increased incidence may be associated to uremia-related factors. the development and progression of coronary artery calcification is similar to osteogenesis. the aim of this study was to evaluate the relationship between coronary artery calcification, uremia-related factors, and bone histomorphometry in hemodialysis patients.Methods. A total of 101 hemodialysis patients were assessed for biochemical markers of inflammation, oxidative stress, and bone metabolism. Subsequently, they were submitted to multislice coronary tomography (MSCT) and transiliac bone biopsy.Results. the median calcium score was 116.2 (range 0 to 5547). Fifty-two percent of the patients showed moderate and severe coronary artery calcification, 20% had calcium scores greater than 1000. in univariate analysis, age (r= 0.57, P < 0.000001), osteoprotegerin (OPG) (r= 0.44, P= 0.00002), and body mass index (BMI) (r= 0.24, P= 0.01) correlated positively with calcium score. Bone trabecular volume and trabecular thickness correlated negatively with calcium score (r=-0.24, P= 0.02; r=-0.22, P= 0.03). There was a correlation of borderline significance between calcium score and C-reactive protein (CRP) (r= 0.18, P= 0.062). the multiple linear regression analysis identified OPG as the only variable independently associated with coronary artery calcification.Conclusion. Coronary artery calcification is highly prevalent in the hemodialysis population and is associated with older age, higher BMI, inflammation and reduced trabecular bone volume. Higher OPG is independently associated with coronary artery calcification and may represent an incomplete self-defensive response to the progression of atherosclerosis in hemodialysis patients. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005-04-01 2016-01-24T12:37:44Z 2016-01-24T12:37:44Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1523-1755.2005.00239.x Kidney International. Malden: Blackwell Publishing Inc, v. 67, n. 4, p. 1576-1582, 2005. 10.1111/j.1523-1755.2005.00239.x 0085-2538 http://repositorio.unifesp.br/handle/11600/28204 WOS:000227596500041 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001zrkv |
| url |
http://dx.doi.org/10.1111/j.1523-1755.2005.00239.x http://repositorio.unifesp.br/handle/11600/28204 |
| identifier_str_mv |
Kidney International. Malden: Blackwell Publishing Inc, v. 67, n. 4, p. 1576-1582, 2005. 10.1111/j.1523-1755.2005.00239.x 0085-2538 WOS:000227596500041 ark:/48912/001300001zrkv |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Kidney International |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1576-1582 |
| dc.publisher.none.fl_str_mv |
Blackwell Publishing Inc |
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Blackwell Publishing Inc |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1853670514623512576 |
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15,301603 |