Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity

Lipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal a...

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Autores: Perossi, Isabela F. S., Martinelli, Paulo E. B., Bonato, Leticia, Lima, Gabriela P. [UNESP], Bertolo, Paulo Henrique L. [UNESP], Costa, Rafael R. M. E. [UNESP], Gómez, Jorge L. A. [UNESP], De Nardi, Andrigo B. [UNESP], Vasconcelos, Rosemeri O. [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/200932
Acceso en línea:http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32
http://hdl.handle.net/11449/200932
Access Level:acceso abierto
Palabra clave:Cytokeratin
Histology
Immunohistochemistry
Necropsy
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spelling Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavityCytokeratinHistologyImmunohistochemistryNecropsyLipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal and inguinal abdominal mammary region was examined. The impossibility of surgical ressection led to euthanasia during the surgical procedure. At necropsy, analysis of the abdominal cavity revealed the presence of an irregularly shaped mass, whitish with red areas, in the intrapelvic region. Also, metastases in axillary and mediastinal lymph nodes and right lung were observed. Histopathological analysis of the tumor in the mammary glands and intrapelvic mass showed malignant neoplastic proliferation of epithelial cells. The cells had a distinct shape and boundary, a well-defined cytoplasm, and the presence of intracytoplasmic macro and micro vacuoles, which sometimes pushed the nuclei to the periphery. The lymph nodes had lost the histological architecture due to metastasis. Marked and diffuse immunostaining of tumor cells in the cytoplasm by pancytokeratin, GATA 3 and 35BH11 confirmed the epithelial origin of the tumor. This very aggressive and uncommon neoplasm should be considered as a possible metastasi in the differential diagnosis of tumors of the abdominal cavity.Profissional Heath Program Resident Med. Vet. e Saúde (MEC/MS)Veterinary Pathology Departemnt-FCAV-UNESPVeterinary Clinic and Surgery Department FCAV-UNESPVeterinary Pathology Departemnt-FCAV-UNESPVeterinary Clinic and Surgery Department FCAV-UNESPProfissional Heath Program Resident Med. Vet. e Saúde (MEC/MS)Universidade Estadual Paulista (Unesp)2020-12-12T02:19:51Z2020-12-12T02:19:51Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article26-32http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020.1983-0246http://hdl.handle.net/11449/20093210.24070/bjvp.1983-0246.v13i1p26-322-s2.0-85089713927Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Pathologyinfo:eu-repo/semantics/openAccessPerossi, Isabela F. S.Martinelli, Paulo E. B.Bonato, LeticiaLima, Gabriela P. [UNESP]Bertolo, Paulo Henrique L. [UNESP]Costa, Rafael R. M. E. [UNESP]Gómez, Jorge L. A. [UNESP]De Nardi, Andrigo B. [UNESP]Vasconcelos, Rosemeri O. [UNESP]2024-06-07T13:02:27Zoai:repositorio.unesp.br:11449/200932Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-06-07T13:02:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
title Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
spellingShingle Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
Perossi, Isabela F. S.
Cytokeratin
Histology
Immunohistochemistry
Necropsy
title_short Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
title_full Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
title_fullStr Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
title_full_unstemmed Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
title_sort Lipid rich carcinoma in canine mammary gland with metastasis in the abdominal cavity
dc.creator.none.fl_str_mv Perossi, Isabela F. S.
Martinelli, Paulo E. B.
Bonato, Leticia
Lima, Gabriela P. [UNESP]
Bertolo, Paulo Henrique L. [UNESP]
Costa, Rafael R. M. E. [UNESP]
Gómez, Jorge L. A. [UNESP]
De Nardi, Andrigo B. [UNESP]
Vasconcelos, Rosemeri O. [UNESP]
author Perossi, Isabela F. S.
author_facet Perossi, Isabela F. S.
Martinelli, Paulo E. B.
Bonato, Leticia
Lima, Gabriela P. [UNESP]
Bertolo, Paulo Henrique L. [UNESP]
Costa, Rafael R. M. E. [UNESP]
Gómez, Jorge L. A. [UNESP]
De Nardi, Andrigo B. [UNESP]
Vasconcelos, Rosemeri O. [UNESP]
author_role author
author2 Martinelli, Paulo E. B.
Bonato, Leticia
Lima, Gabriela P. [UNESP]
Bertolo, Paulo Henrique L. [UNESP]
Costa, Rafael R. M. E. [UNESP]
Gómez, Jorge L. A. [UNESP]
De Nardi, Andrigo B. [UNESP]
Vasconcelos, Rosemeri O. [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Profissional Heath Program Resident Med. Vet. e Saúde (MEC/MS)
Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Cytokeratin
Histology
Immunohistochemistry
Necropsy
topic Cytokeratin
Histology
Immunohistochemistry
Necropsy
description Lipid-rich carcinoma of the mammary gland is a rare variant of cancer and extremely uncommon in dogs. This case report describes the clinical and histopathological aspects of lipid-rich carcinoma in a female dog. A four-year-old spaeyd German Shepherd dog with enlarged volume adhered to the caudal and inguinal abdominal mammary region was examined. The impossibility of surgical ressection led to euthanasia during the surgical procedure. At necropsy, analysis of the abdominal cavity revealed the presence of an irregularly shaped mass, whitish with red areas, in the intrapelvic region. Also, metastases in axillary and mediastinal lymph nodes and right lung were observed. Histopathological analysis of the tumor in the mammary glands and intrapelvic mass showed malignant neoplastic proliferation of epithelial cells. The cells had a distinct shape and boundary, a well-defined cytoplasm, and the presence of intracytoplasmic macro and micro vacuoles, which sometimes pushed the nuclei to the periphery. The lymph nodes had lost the histological architecture due to metastasis. Marked and diffuse immunostaining of tumor cells in the cytoplasm by pancytokeratin, GATA 3 and 35BH11 confirmed the epithelial origin of the tumor. This very aggressive and uncommon neoplasm should be considered as a possible metastasi in the differential diagnosis of tumors of the abdominal cavity.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:19:51Z
2020-12-12T02:19:51Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32
Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020.
1983-0246
http://hdl.handle.net/11449/200932
10.24070/bjvp.1983-0246.v13i1p26-32
2-s2.0-85089713927
url http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p26-32
http://hdl.handle.net/11449/200932
identifier_str_mv Brazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 26-32, 2020.
1983-0246
10.24070/bjvp.1983-0246.v13i1p26-32
2-s2.0-85089713927
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Veterinary Pathology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 26-32
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853672008500379648
score 15,301603

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