Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety

Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions th...

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Autores: Diniz, Juliana Belo, Miguel, Euripedes Constantino, Oliveira, Amanda Ribeiro de, Reimer, Adriano Edgar, Brandao, Marcus Lira, Mathis, Maria Alice de, Batistuzzo, Marcelo Camargo, Costa, Daniel Lucas Conceicao, Hoexter, Marcelo Queiroz [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/45405
Acceso en línea:http://dx.doi.org/10.1590/S1516-44462012000500007
http://repositorio.unifesp.br/handle/11600/45405
Access Level:acceso abierto
Palabra clave:Obsessive-Compulsive Disorder
Anxiety Disorders
Fear
Stress Disorders
Post-Traumatic
Neuroimaging
Epidemiology
Treatment
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spelling Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxietyDesenhando as novas fronteiras para a compreensão do transtorno obsessivo-compulsivo: uma revisão de sua relação com o medo e a ansiedadeObsessive-Compulsive DisorderAnxiety DisordersFearStress DisordersPost-TraumaticNeuroimagingEpidemiologyTreatmentAnxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. Objectives: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. Results: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. Conclusion: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response.Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Psicobiol, BR-14049 Ribeirao Preto, BrazilInst Neurosci & Behav, Ribeirao Preto, BrazilUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Hosp Clin, Dept & Inst Psychiat, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo, BrazilWeb of ScienceGlobal Research Awards for Nicotine Dependence (GRAND) from Pfizer U.S.Assoc Brasileira PsiquiatriaUniversidade de São Paulo (USP)Inst Neurosci & BehavUniversidade Federal de São Paulo (UNIFESP)2018-06-18T11:48:17Z2018-06-18T11:48:17Z2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionS81-S103application/pdfapplication/pdfhttp://dx.doi.org/10.1590/S1516-44462012000500007Revista Brasileira De Psiquiatria. Sao Paulo: Assoc Brasileira Psiquiatria, v. 34, p. S81-S103, 2012.10.1590/S1516-44462012000500007S1516-44462012000500007-pt.pdfS1516-44462012000500007-en.pdf1516-4446S1516-44462012000500007http://repositorio.unifesp.br/handle/11600/45405WOS:000305441200007ark:/48912/001300001mqhhengRevista Brasileira De Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPDiniz, Juliana BeloMiguel, Euripedes ConstantinoOliveira, Amanda Ribeiro deReimer, Adriano EdgarBrandao, Marcus LiraMathis, Maria Alice deBatistuzzo, Marcelo CamargoCosta, Daniel Lucas ConceicaoHoexter, Marcelo Queiroz [UNIFESP]2024-08-02T07:31:42Zoai:repositorio.unifesp.br:11600/45405Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-02T07:31:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
Desenhando as novas fronteiras para a compreensão do transtorno obsessivo-compulsivo: uma revisão de sua relação com o medo e a ansiedade
title Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
spellingShingle Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
Diniz, Juliana Belo
Obsessive-Compulsive Disorder
Anxiety Disorders
Fear
Stress Disorders
Post-Traumatic
Neuroimaging
Epidemiology
Treatment
title_short Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
title_full Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
title_fullStr Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
title_full_unstemmed Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
title_sort Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
dc.creator.none.fl_str_mv Diniz, Juliana Belo
Miguel, Euripedes Constantino
Oliveira, Amanda Ribeiro de
Reimer, Adriano Edgar
Brandao, Marcus Lira
Mathis, Maria Alice de
Batistuzzo, Marcelo Camargo
Costa, Daniel Lucas Conceicao
Hoexter, Marcelo Queiroz [UNIFESP]
author Diniz, Juliana Belo
author_facet Diniz, Juliana Belo
Miguel, Euripedes Constantino
Oliveira, Amanda Ribeiro de
Reimer, Adriano Edgar
Brandao, Marcus Lira
Mathis, Maria Alice de
Batistuzzo, Marcelo Camargo
Costa, Daniel Lucas Conceicao
Hoexter, Marcelo Queiroz [UNIFESP]
author_role author
author2 Miguel, Euripedes Constantino
Oliveira, Amanda Ribeiro de
Reimer, Adriano Edgar
Brandao, Marcus Lira
Mathis, Maria Alice de
Batistuzzo, Marcelo Camargo
Costa, Daniel Lucas Conceicao
Hoexter, Marcelo Queiroz [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Inst Neurosci & Behav
Universidade Federal de São Paulo (UNIFESP)
dc.subject.por.fl_str_mv Obsessive-Compulsive Disorder
Anxiety Disorders
Fear
Stress Disorders
Post-Traumatic
Neuroimaging
Epidemiology
Treatment
topic Obsessive-Compulsive Disorder
Anxiety Disorders
Fear
Stress Disorders
Post-Traumatic
Neuroimaging
Epidemiology
Treatment
description Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. Objectives: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. Results: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. Conclusion: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2018-06-18T11:48:17Z
2018-06-18T11:48:17Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-44462012000500007
Revista Brasileira De Psiquiatria. Sao Paulo: Assoc Brasileira Psiquiatria, v. 34, p. S81-S103, 2012.
10.1590/S1516-44462012000500007
S1516-44462012000500007-pt.pdf
S1516-44462012000500007-en.pdf
1516-4446
S1516-44462012000500007
http://repositorio.unifesp.br/handle/11600/45405
WOS:000305441200007
dc.identifier.dark.fl_str_mv ark:/48912/001300001mqhh
url http://dx.doi.org/10.1590/S1516-44462012000500007
http://repositorio.unifesp.br/handle/11600/45405
identifier_str_mv Revista Brasileira De Psiquiatria. Sao Paulo: Assoc Brasileira Psiquiatria, v. 34, p. S81-S103, 2012.
10.1590/S1516-44462012000500007
S1516-44462012000500007-pt.pdf
S1516-44462012000500007-en.pdf
1516-4446
S1516-44462012000500007
WOS:000305441200007
ark:/48912/001300001mqhh
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira De Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv S81-S103
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Assoc Brasileira Psiquiatria
publisher.none.fl_str_mv Assoc Brasileira Psiquiatria
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15.301603

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