Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC
Dexamethasone acetate (DEX), a potent anti-inflammatory, is used primarily in the treatment of inflammatory and autoimmune diseases. It was incorporated in CETETH 20 (polyoxyethylene 20 cetyl alcohol)–based liquid crystalline systems to enhance the purpose of the drug. Concomitant with the pharmaceu...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/207150 |
| Acceso en línea: | http://dx.doi.org/10.1002/bmc.5054 http://hdl.handle.net/11449/207150 |
| Access Level: | acceso abierto |
| Palabra clave: | anti-inflammatory CETETH 20 dexamethasone acetate HPLC liquid crystalline systems |
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Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLCanti-inflammatoryCETETH 20dexamethasone acetateHPLCliquid crystalline systemsDexamethasone acetate (DEX), a potent anti-inflammatory, is used primarily in the treatment of inflammatory and autoimmune diseases. It was incorporated in CETETH 20 (polyoxyethylene 20 cetyl alcohol)–based liquid crystalline systems to enhance the purpose of the drug. Concomitant with the pharmaceutical technology performed, a HPLC method was developed and validated for the quantification of dexamethasone acetate in CETETH 20-based liquid crystalline systems for the evaluation of the drug in the new matrix. The method was performed using a C18 column with acetonitrile:methanol:water (35:35:30, v/v/v) as the mobile phase at a flow rate of 0.8 mL min−1 at 239 nm. The method was linear in the range of 1–25 μg mL−1; the limit of quantification and limit of detection were 0.05 and 0.16 μg mL−1, respectively; the accuracy of the method was 99.92% (relative standard deviation < 1%), and it presented intra-day and inter-day precision with deviations less than 1%. In this context, the method was successfully used to determine the incorporation efficiency of DEX in CETETH 20-based liquid crystalline systems and can be easily used by pharmaceutical companies and laboratories around the world.Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Laboratório de Controle de Qualidade Faculdade de Farmácia Universidade Federal de Goiás—UFGDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Universidade Federal de Goiás (UFG)2021-06-25T10:49:45Z2021-06-25T10:49:45Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/bmc.5054Biomedical Chromatography, v. 35, n. 5, 2021.1099-08010269-3879http://hdl.handle.net/11449/20715010.1002/bmc.50542-s2.0-85099521955Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomedical Chromatographyinfo:eu-repo/semantics/openAccessOyafuso, Márcia Helena [UNESP]Fonseca-Santos, Bruno [UNESP]Kogawa, Ana CarolinaCarvalho, Flávia Chiva [UNESP]Gremião, Maria Palmira Daflon [UNESP]Chorilli, Marlus [UNESP]2025-03-29T05:17:08Zoai:repositorio.unesp.br:11449/207150Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-03-29T05:17:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| title |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| spellingShingle |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC Oyafuso, Márcia Helena [UNESP] anti-inflammatory CETETH 20 dexamethasone acetate HPLC liquid crystalline systems |
| title_short |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| title_full |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| title_fullStr |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| title_full_unstemmed |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| title_sort |
Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC |
| dc.creator.none.fl_str_mv |
Oyafuso, Márcia Helena [UNESP] Fonseca-Santos, Bruno [UNESP] Kogawa, Ana Carolina Carvalho, Flávia Chiva [UNESP] Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
| author |
Oyafuso, Márcia Helena [UNESP] |
| author_facet |
Oyafuso, Márcia Helena [UNESP] Fonseca-Santos, Bruno [UNESP] Kogawa, Ana Carolina Carvalho, Flávia Chiva [UNESP] Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
| author_role |
author |
| author2 |
Fonseca-Santos, Bruno [UNESP] Kogawa, Ana Carolina Carvalho, Flávia Chiva [UNESP] Gremião, Maria Palmira Daflon [UNESP] Chorilli, Marlus [UNESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Goiás (UFG) |
| dc.subject.por.fl_str_mv |
anti-inflammatory CETETH 20 dexamethasone acetate HPLC liquid crystalline systems |
| topic |
anti-inflammatory CETETH 20 dexamethasone acetate HPLC liquid crystalline systems |
| description |
Dexamethasone acetate (DEX), a potent anti-inflammatory, is used primarily in the treatment of inflammatory and autoimmune diseases. It was incorporated in CETETH 20 (polyoxyethylene 20 cetyl alcohol)–based liquid crystalline systems to enhance the purpose of the drug. Concomitant with the pharmaceutical technology performed, a HPLC method was developed and validated for the quantification of dexamethasone acetate in CETETH 20-based liquid crystalline systems for the evaluation of the drug in the new matrix. The method was performed using a C18 column with acetonitrile:methanol:water (35:35:30, v/v/v) as the mobile phase at a flow rate of 0.8 mL min−1 at 239 nm. The method was linear in the range of 1–25 μg mL−1; the limit of quantification and limit of detection were 0.05 and 0.16 μg mL−1, respectively; the accuracy of the method was 99.92% (relative standard deviation < 1%), and it presented intra-day and inter-day precision with deviations less than 1%. In this context, the method was successfully used to determine the incorporation efficiency of DEX in CETETH 20-based liquid crystalline systems and can be easily used by pharmaceutical companies and laboratories around the world. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-06-25T10:49:45Z 2021-06-25T10:49:45Z 2021-05-01 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/bmc.5054 Biomedical Chromatography, v. 35, n. 5, 2021. 1099-0801 0269-3879 http://hdl.handle.net/11449/207150 10.1002/bmc.5054 2-s2.0-85099521955 |
| url |
http://dx.doi.org/10.1002/bmc.5054 http://hdl.handle.net/11449/207150 |
| identifier_str_mv |
Biomedical Chromatography, v. 35, n. 5, 2021. 1099-0801 0269-3879 10.1002/bmc.5054 2-s2.0-85099521955 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Biomedical Chromatography |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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15,300719 |