Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid
Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA)...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/69193 |
| Acceso en línea: | http://dx.doi.org/10.1248/bpb.29.2236 http://hdl.handle.net/11449/69193 |
| Access Level: | acceso abierto |
| Palabra clave: | Analgesic Anti-inflammatory Carrageenin Chlorogenic acid Formalin Lipopolysaccharide (LPS) chlorogenic acid lipopolysaccharide polyphenol derivative analgesic activity animal experiment animal model antiinflammatory activity antineoplastic activity antinociception antioxidant activity antipyretic activity controlled study dose response drug effect drug inhibition fever inflammation male nonhuman pain assessment paw edema rat Administration, Oral Analgesics Analgesics, Non-Narcotic Animals Anti-Inflammatory Agents, Non-Steroidal Carrageenan Chlorogenic Acid Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Edema Fever Flavonoids Formaldehyde Hindlimb Inflammation Lipopolysaccharides Male Molecular Structure Pain Phenols Rats Rats, Wistar Time Factors |
| Sumario: | Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA. © 2006 Pharmaceutical Society of Japan. |
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