New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains
Objective: To evaluate the impact of new penicillin susceptibility breakpoints on resistance rates of pneumococcal strains collected from children with pneumonia.Methods: Pneumococcal strains collected from patients admitted with pneumonia were isolated at the clinical analysis lab of Hospital de Cl...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | Brasil |
| Recursos: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/31763 |
| Acesso em linha: | http://dx.doi.org/10.2223/JPED.1931 http://repositorio.unifesp.br/handle/11600/31763 |
| Access Level: | acceso abierto |
| Palavra-chave: | Pneumococcus antimicrobial resistance pneumonia |
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New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strainsNovos pontos de corte de sensibilidade nas taxas de resistência antimicrobiana de cepas invasivas de pneumococoPneumococcusantimicrobial resistancepneumoniaObjective: To evaluate the impact of new penicillin susceptibility breakpoints on resistance rates of pneumococcal strains collected from children with pneumonia.Methods: Pneumococcal strains collected from patients admitted with pneumonia were isolated at the clinical analysis lab of Hospital de Clinicas de Uberlandia, Uberlandia, Brazil, and sent to Instituto Adolfo Lutz, São Paulo, Brazil, for further identification, serotyping and determination of antimicrobial susceptibility.Results: From April 1999 to December 2008, 330 strains of pneumococcus were sent to Instituto Adolfo Lutz; of these, 195 (59%) were collected from patients with pneumonia. One hundred strains collected from patients <= 12 years old were analyzed. the patients' age ranged from 1 to 12.6 years old (with mean age of 2.4 and median of 1.7 years). Forty-seven patients were male. the strains were isolated from blood (42%) and pleural fluid (58%). There were 35 oxacillin-resistant strains: according to the criteria defined by the Clinical and Laboratory Standards Institute (CLSI) in 2007 [minimum inhibitory concentration (MIC) <= 0.06 mu g/mL for susceptibility (S), 0.12 to 1 mu g/mL for intermediate resistance (IR), and <= 2 mu g/mL for full resistance (FR)], 22 strains had IR and 11 strains had FR. According to the current breakpoints defined by the CLSI in 2008 (<= 2 mu g/mL for S, 4 mu g/mL for IR and >= 8 mu g/mL for FR), only one strain had IR to penicillin. There was resistance to co-trimoxazole (80%), tetracycline (21%), erythromycin (13%), clindamycin (13%), and ceftriaxone (one strain simultaneously resistant to penicillin).Conclusions: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%.Univ Fed Uberlandia, Fac Med, Programa Posgrad Ciencias Saude, BR-38400 Uberlandia, MG, BrazilUniv Fed Paulista UNIFESP, São Paulo, BrazilUniv Fed Uberlandia, Lab Hosp Clin Uberlandia, Fac Med, BR-38400 Uberlandia, MG, BrazilUniv São Paulo, São Paulo, BrazilIAL, São Paulo, BrazilUNIFESP EPM, São Paulo, BrazilUniv Fed Paulista UNIFESP, São Paulo, BrazilUNIFESP EPM, São Paulo, BrazilWeb of ScienceSoc Brasil PediatriaUniversidade Federal de Uberlândia (UFU)Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)IAL2016-01-24T13:58:39Z2016-01-24T13:58:39Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion421-425http://dx.doi.org/10.2223/JPED.1931Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 85, n. 5, p. 421-425, 2009.10.2223/JPED.1931S0021-75572009000500009-en.pdfS0021-75572009000500009-pt.pdf0021-7557S0021-75572009000500009http://repositorio.unifesp.br/handle/11600/31763WOS:000271570200009ark:/48912/001300001vxjhengJornal de Pediatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPWolkers, Paula Carolina BejoMantese, Orlando Cesar [UNIFESP]Paula, Alan deAlmeida, Vivieni Vieira PradoAguiar, Paula Augusta Dias Fogaca deAlvares, Jackelline Rodrigues [UNIFESP]Almeida, Samanta Cristine Grassi [UNIFESP]Brandileone, Maria Cristina de Cunto [UNIFESP]2023-02-15T10:46:35Zoai:repositorio.unifesp.br:11600/31763Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:46:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains Novos pontos de corte de sensibilidade nas taxas de resistência antimicrobiana de cepas invasivas de pneumococo |
| title |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| spellingShingle |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains Wolkers, Paula Carolina Bejo Pneumococcus antimicrobial resistance pneumonia |
| title_short |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| title_full |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| title_fullStr |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| title_full_unstemmed |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| title_sort |
New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains |
| dc.creator.none.fl_str_mv |
Wolkers, Paula Carolina Bejo Mantese, Orlando Cesar [UNIFESP] Paula, Alan de Almeida, Vivieni Vieira Prado Aguiar, Paula Augusta Dias Fogaca de Alvares, Jackelline Rodrigues [UNIFESP] Almeida, Samanta Cristine Grassi [UNIFESP] Brandileone, Maria Cristina de Cunto [UNIFESP] |
| author |
Wolkers, Paula Carolina Bejo |
| author_facet |
Wolkers, Paula Carolina Bejo Mantese, Orlando Cesar [UNIFESP] Paula, Alan de Almeida, Vivieni Vieira Prado Aguiar, Paula Augusta Dias Fogaca de Alvares, Jackelline Rodrigues [UNIFESP] Almeida, Samanta Cristine Grassi [UNIFESP] Brandileone, Maria Cristina de Cunto [UNIFESP] |
| author_role |
author |
| author2 |
Mantese, Orlando Cesar [UNIFESP] Paula, Alan de Almeida, Vivieni Vieira Prado Aguiar, Paula Augusta Dias Fogaca de Alvares, Jackelline Rodrigues [UNIFESP] Almeida, Samanta Cristine Grassi [UNIFESP] Brandileone, Maria Cristina de Cunto [UNIFESP] |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de Uberlândia (UFU) Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) IAL |
| dc.subject.por.fl_str_mv |
Pneumococcus antimicrobial resistance pneumonia |
| topic |
Pneumococcus antimicrobial resistance pneumonia |
| description |
Objective: To evaluate the impact of new penicillin susceptibility breakpoints on resistance rates of pneumococcal strains collected from children with pneumonia.Methods: Pneumococcal strains collected from patients admitted with pneumonia were isolated at the clinical analysis lab of Hospital de Clinicas de Uberlandia, Uberlandia, Brazil, and sent to Instituto Adolfo Lutz, São Paulo, Brazil, for further identification, serotyping and determination of antimicrobial susceptibility.Results: From April 1999 to December 2008, 330 strains of pneumococcus were sent to Instituto Adolfo Lutz; of these, 195 (59%) were collected from patients with pneumonia. One hundred strains collected from patients <= 12 years old were analyzed. the patients' age ranged from 1 to 12.6 years old (with mean age of 2.4 and median of 1.7 years). Forty-seven patients were male. the strains were isolated from blood (42%) and pleural fluid (58%). There were 35 oxacillin-resistant strains: according to the criteria defined by the Clinical and Laboratory Standards Institute (CLSI) in 2007 [minimum inhibitory concentration (MIC) <= 0.06 mu g/mL for susceptibility (S), 0.12 to 1 mu g/mL for intermediate resistance (IR), and <= 2 mu g/mL for full resistance (FR)], 22 strains had IR and 11 strains had FR. According to the current breakpoints defined by the CLSI in 2008 (<= 2 mu g/mL for S, 4 mu g/mL for IR and >= 8 mu g/mL for FR), only one strain had IR to penicillin. There was resistance to co-trimoxazole (80%), tetracycline (21%), erythromycin (13%), clindamycin (13%), and ceftriaxone (one strain simultaneously resistant to penicillin).Conclusions: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-09-01 2016-01-24T13:58:39Z 2016-01-24T13:58:39Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2223/JPED.1931 Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 85, n. 5, p. 421-425, 2009. 10.2223/JPED.1931 S0021-75572009000500009-en.pdf S0021-75572009000500009-pt.pdf 0021-7557 S0021-75572009000500009 http://repositorio.unifesp.br/handle/11600/31763 WOS:000271570200009 |
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ark:/48912/001300001vxjh |
| url |
http://dx.doi.org/10.2223/JPED.1931 http://repositorio.unifesp.br/handle/11600/31763 |
| identifier_str_mv |
Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 85, n. 5, p. 421-425, 2009. 10.2223/JPED.1931 S0021-75572009000500009-en.pdf S0021-75572009000500009-pt.pdf 0021-7557 S0021-75572009000500009 WOS:000271570200009 ark:/48912/001300001vxjh |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Jornal de Pediatria |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
421-425 |
| dc.publisher.none.fl_str_mv |
Soc Brasil Pediatria |
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Soc Brasil Pediatria |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1853670501107367936 |
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15,301629 |