Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae)

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-preci...

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Detalles Bibliográficos
Autores: Medina, Rebeca P. [UNESP], de Moura, Vagner M., da Silva, Cleuza C., de Oliveira, Cecília M. A., Kato, Lucilia, Pomini, Armando M., de Carvalho, João E., Ruiz, Ana Lúcia T. G., Bersani-Amado, Ciomar A., Santin, Silvana M. O.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/174792
Acceso en línea:http://dx.doi.org/10.1080/14786419.2017.1344654
http://hdl.handle.net/11449/174792
Access Level:acceso abierto
Palabra clave:anti-inflammatory activity
antiproliferative activity
Ixora brevifolia
Rubiaceae
Descripción
Sumario:The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.

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