Alterations of spermatogenesis in etoposide-treated rats: A stereological study

The etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light microscopy according to histomorphometric and stereological parameters. Rand...

Descripción completa

Detalles Bibliográficos
Autores: Freitas, Francisca Estela Lima [UNIFESP], Mori, Flora Cordeiro [UNIFESP]|Sasso-Cerri, Estela [UNIFESP], Lucas, Sandra Regina Rodrigues [UNIFESP], Miraglia, Sandra Maria [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2002
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/43984
Acceso en línea:http://www.redalyc.org/articulo.oa?id=33906803
http://repositorio.unifesp.br/handle/11600/43984
Access Level:acceso abierto
Palabra clave:etoposide
seminiferous epithelium
spermatogenesis
testis
topoisomerase
id BR_850dbd5bc2b3fc3ad00db2bca6668f07
oai_identifier_str oai:repositorio.unifesp.br:11600/43984
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Alterations of spermatogenesis in etoposide-treated rats: A stereological studyetoposideseminiferous epitheliumspermatogenesistestistopoisomeraseThe etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light microscopy according to histomorphometric and stereological parameters. Random 3mum-thick-paraplast sections of testis were stained with periodic acid-Schiff reaction and Harris' hematoxylin method. Serum testosterone level and reproductive performance were also investigated. The results showed an accentuated decrease in the frequency of germinal lineage cell types and differentiated spermatogonia were the most affected cell types. Morphometric and stereological testicular parameters exhibited highly, significant reductions in adult etoposide-treated rats. Their reproductive performance diminished but their serum testosterone level was not significantly altered. The mortality frequency of the progenies was 100%.UNIFESP, Lab Embryol, Dept Morphol, BR-04580000 Sao Paulo, BrazilFed Univ Acre, Lab Nat Sci, Rio Branco, BrazilUniv Estadual Paulista, Dept Hlth Sci, Sao Paulo, BrazilUNIFESP, Lab Embryol, Dept Morphol, BR-04580000 Sao Paulo, BrazilWeb of ScienceIntercienciaUniversidade Federal de São Paulo (UNIFESP)Fed Univ AcreUniv Estadual Paulista2018-06-15T17:44:09Z2018-06-15T17:44:09Z2002-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion227-235application/pdfhttp://www.redalyc.org/articulo.oa?id=33906803Interciencia. Caracas: Interciencia, v. 27, n. 5, p. 227-235, 2002.WOS000175969700003.pdf0378-1844http://repositorio.unifesp.br/handle/11600/43984WOS:000175969700003ark:/48912/00130000288hwengIntercienciainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPFreitas, Francisca Estela Lima [UNIFESP]Mori, Flora Cordeiro [UNIFESP]|Sasso-Cerri, Estela [UNIFESP]Lucas, Sandra Regina Rodrigues [UNIFESP]Miraglia, Sandra Maria [UNIFESP]2024-08-09T18:35:52Zoai:repositorio.unifesp.br:11600/43984Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-09T18:35:52Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Alterations of spermatogenesis in etoposide-treated rats: A stereological study
title Alterations of spermatogenesis in etoposide-treated rats: A stereological study
spellingShingle Alterations of spermatogenesis in etoposide-treated rats: A stereological study
Freitas, Francisca Estela Lima [UNIFESP]
etoposide
seminiferous epithelium
spermatogenesis
testis
topoisomerase
title_short Alterations of spermatogenesis in etoposide-treated rats: A stereological study
title_full Alterations of spermatogenesis in etoposide-treated rats: A stereological study
title_fullStr Alterations of spermatogenesis in etoposide-treated rats: A stereological study
title_full_unstemmed Alterations of spermatogenesis in etoposide-treated rats: A stereological study
title_sort Alterations of spermatogenesis in etoposide-treated rats: A stereological study
dc.creator.none.fl_str_mv Freitas, Francisca Estela Lima [UNIFESP]
Mori, Flora Cordeiro [UNIFESP]|Sasso-Cerri, Estela [UNIFESP]
Lucas, Sandra Regina Rodrigues [UNIFESP]
Miraglia, Sandra Maria [UNIFESP]
author Freitas, Francisca Estela Lima [UNIFESP]
author_facet Freitas, Francisca Estela Lima [UNIFESP]
Mori, Flora Cordeiro [UNIFESP]|Sasso-Cerri, Estela [UNIFESP]
Lucas, Sandra Regina Rodrigues [UNIFESP]
Miraglia, Sandra Maria [UNIFESP]
author_role author
author2 Mori, Flora Cordeiro [UNIFESP]|Sasso-Cerri, Estela [UNIFESP]
Lucas, Sandra Regina Rodrigues [UNIFESP]
Miraglia, Sandra Maria [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Fed Univ Acre
Univ Estadual Paulista
dc.subject.por.fl_str_mv etoposide
seminiferous epithelium
spermatogenesis
testis
topoisomerase
topic etoposide
seminiferous epithelium
spermatogenesis
testis
topoisomerase
description The etoposide is an anticancer drug that interacts with topoisomerase II. Thirty-day-old rats received intraperitonially 2mg/kg of etoposide for 30 consecutive days. Their testes were analyzed in the adult phase under light microscopy according to histomorphometric and stereological parameters. Random 3mum-thick-paraplast sections of testis were stained with periodic acid-Schiff reaction and Harris' hematoxylin method. Serum testosterone level and reproductive performance were also investigated. The results showed an accentuated decrease in the frequency of germinal lineage cell types and differentiated spermatogonia were the most affected cell types. Morphometric and stereological testicular parameters exhibited highly, significant reductions in adult etoposide-treated rats. Their reproductive performance diminished but their serum testosterone level was not significantly altered. The mortality frequency of the progenies was 100%.
publishDate 2002
dc.date.none.fl_str_mv 2002-05-01
2018-06-15T17:44:09Z
2018-06-15T17:44:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.redalyc.org/articulo.oa?id=33906803
Interciencia. Caracas: Interciencia, v. 27, n. 5, p. 227-235, 2002.
WOS000175969700003.pdf
0378-1844
http://repositorio.unifesp.br/handle/11600/43984
WOS:000175969700003
dc.identifier.dark.fl_str_mv ark:/48912/00130000288hw
url http://www.redalyc.org/articulo.oa?id=33906803
http://repositorio.unifesp.br/handle/11600/43984
identifier_str_mv Interciencia. Caracas: Interciencia, v. 27, n. 5, p. 227-235, 2002.
WOS000175969700003.pdf
0378-1844
WOS:000175969700003
ark:/48912/00130000288hw
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Interciencia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 227-235
application/pdf
dc.publisher.none.fl_str_mv Interciencia
publisher.none.fl_str_mv Interciencia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1853670552879759360
score 15,301629

Similares en LA Referencia