Healing properties of papain-based gel on oral ulcers

The oral mucous membrane is prone to developing ulcers originating from traumatic or immunological processes. Aim: The aim of the present study was to perform a histological evaluation of the antiinflammatory and healing properties of PapacarieTM applied to oral ulcers. Methods: Fifty adult female a...

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Autores: Martins, Manoela Domingues, Fernandes, Kristianne Porta Santos, Pavesi, Vanessa Christina Santos, França, Cristiane Miranda, Mesquita-Ferrari, Raquel Agnelli, Bussadori, Sandra Kalil
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Recursos:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/149231
Acesso em linha:http://hdl.handle.net/10183/149231
Access Level:acceso abierto
Palavra-chave:Mucosa bucal : Doencas
Patologia bucal
Papain
Oral ulcer
Wistar
Wound healing
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spelling 2016-10-26T02:19:30Z20111677-3217http://hdl.handle.net/10183/149231000826210The oral mucous membrane is prone to developing ulcers originating from traumatic or immunological processes. Aim: The aim of the present study was to perform a histological evaluation of the antiinflammatory and healing properties of PapacarieTM applied to oral ulcers. Methods: Fifty adult female albino Wistar rats were randomly separated into two groups: control and PapacarieTM. The animals were anesthetized, placed in prone position and ulcers were induced in the middle dorsum of the tongue through a 3-mm-diameter punch. The control group received no treatment thereafter, while those in the PapacarieTM group received an application of the gel twice a day for 14 days. Five animals from each group were euthanized on days 1, 3, 5, 7 and 14. The tongues were removed, fixed, routinely processed for hematoxylin-eosin staining and analyzed by two blind, calibrated pathologists for the presence or absence of ulcer, inflammatory infiltrate and neutrophils. Data were submitted to statistical analysis by the Fisher’s exact test. Results: On day 1, both groups exhibited ulceration and dense acute inflammatory infiltrate. On day 5, reepithelization and scanty chronic inflammatory infiltrate were observed. On day 14, all animals were healed. There were no statistically significant differences between groups with regard to ulceration (p=0.81), inflammation (p=0.55) or neutrophils (p=0.53). Conclusions: Oral ulcers treated with a papainbased gel exhibited the same inflammatory reaction and healing aspects as those of the nontreated control group.application/pdfengBrazilian journal of oral sciences. Piracicaba. Vol. 10, no. 2 (Apr./June 2011), p. 120-123Mucosa bucal : DoencasPatologia bucalPapainOral ulcerWistarWound healingHealing properties of papain-based gel on oral ulcersinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSMartins, Manoela DominguesFernandes, Kristianne Porta SantosPavesi, Vanessa Christina SantosFrança, Cristiane MirandaMesquita-Ferrari, Raquel AgnelliBussadori, Sandra KalilORIGINAL000826210.pdf000826210.pdfTexto completo (inglês)application/pdf730404http://www.lume.ufrgs.br/bitstream/10183/149231/1/000826210.pdf07c6a850708f1193f9e23d6565583ca6MD51TEXT000826210.pdf.txt000826210.pdf.txtExtracted Texttext/plain16449http://www.lume.ufrgs.br/bitstream/10183/149231/2/000826210.pdf.txt8a21ec9654b479906175c78a83528aecMD52THUMBNAIL000826210.pdf.jpg000826210.pdf.jpgGenerated Thumbnailimage/jpeg1845http://www.lume.ufrgs.br/bitstream/10183/149231/3/000826210.pdf.jpgf05c517ae89967dc8ad5026ed4853d40MD5310183/1492312025-01-12 07:39:34.891556oai:www.lume.ufrgs.br:10183/149231Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2025-01-12T09:39:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Healing properties of papain-based gel on oral ulcers
title Healing properties of papain-based gel on oral ulcers
spellingShingle Healing properties of papain-based gel on oral ulcers
Martins, Manoela Domingues
Mucosa bucal : Doencas
Patologia bucal
Papain
Oral ulcer
Wistar
Wound healing
title_short Healing properties of papain-based gel on oral ulcers
title_full Healing properties of papain-based gel on oral ulcers
title_fullStr Healing properties of papain-based gel on oral ulcers
title_full_unstemmed Healing properties of papain-based gel on oral ulcers
title_sort Healing properties of papain-based gel on oral ulcers
dc.creator.none.fl_str_mv Martins, Manoela Domingues
Fernandes, Kristianne Porta Santos
Pavesi, Vanessa Christina Santos
França, Cristiane Miranda
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
author Martins, Manoela Domingues
author_facet Martins, Manoela Domingues
Fernandes, Kristianne Porta Santos
Pavesi, Vanessa Christina Santos
França, Cristiane Miranda
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
author_role author
author2 Fernandes, Kristianne Porta Santos
Pavesi, Vanessa Christina Santos
França, Cristiane Miranda
Mesquita-Ferrari, Raquel Agnelli
Bussadori, Sandra Kalil
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv Mucosa bucal : Doencas
Patologia bucal
topic Mucosa bucal : Doencas
Patologia bucal
Papain
Oral ulcer
Wistar
Wound healing
dc.subject.eng.fl_str_mv Papain
Oral ulcer
Wistar
Wound healing
description The oral mucous membrane is prone to developing ulcers originating from traumatic or immunological processes. Aim: The aim of the present study was to perform a histological evaluation of the antiinflammatory and healing properties of PapacarieTM applied to oral ulcers. Methods: Fifty adult female albino Wistar rats were randomly separated into two groups: control and PapacarieTM. The animals were anesthetized, placed in prone position and ulcers were induced in the middle dorsum of the tongue through a 3-mm-diameter punch. The control group received no treatment thereafter, while those in the PapacarieTM group received an application of the gel twice a day for 14 days. Five animals from each group were euthanized on days 1, 3, 5, 7 and 14. The tongues were removed, fixed, routinely processed for hematoxylin-eosin staining and analyzed by two blind, calibrated pathologists for the presence or absence of ulcer, inflammatory infiltrate and neutrophils. Data were submitted to statistical analysis by the Fisher’s exact test. Results: On day 1, both groups exhibited ulceration and dense acute inflammatory infiltrate. On day 5, reepithelization and scanty chronic inflammatory infiltrate were observed. On day 14, all animals were healed. There were no statistically significant differences between groups with regard to ulceration (p=0.81), inflammation (p=0.55) or neutrophils (p=0.53). Conclusions: Oral ulcers treated with a papainbased gel exhibited the same inflammatory reaction and healing aspects as those of the nontreated control group.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-10-26T02:19:30Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/149231
dc.identifier.issn.pt_BR.fl_str_mv 1677-3217
dc.identifier.nrb.pt_BR.fl_str_mv 000826210
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url http://hdl.handle.net/10183/149231
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of oral sciences. Piracicaba. Vol. 10, no. 2 (Apr./June 2011), p. 120-123
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
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instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
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