Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.

Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elementa...

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Detalhes bibliográficos
Autores: Barbosa, Marília Imaculada Frazão, Correa, Rodrigo de Souza, Macedo, Adriana Pereira Mundim Guedes, Graça, Alex Marchezini, Andrade, Francyelli Mello, Leite, Celisnolia Morais, Lacerda, Elisângela de Paula Silveira, Ellena, Javier Alcides, Silva, Henrique Vieira Reis, Doriguetto, Antônio Carlos, Batista, Alzir Azevedo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Recursos:Universidade Federal de Ouro Preto (UFOP)
Repositorio:Repositório Institucional da UFOP
Idioma:inglés
OAI Identifier:oai:repositorio.ufop.br:123456789/17871
Acesso em linha:http://www.repositorio.ufop.br/jspui/handle/123456789/17871
https://doi.org/10.3390/inorganics11070270
Access Level:acceso abierto
Palavra-chave:Ruthenium
Diphenylphosphine
Amino acids
Nitric oxide
Breast cancer cells
Descrição
Resumo:Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.

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