Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that hep...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/159451 |
| Acceso en línea: | http://dx.doi.org/10.1016/j.antiviral.2016.12.023 http://hdl.handle.net/11449/159451 |
| Access Level: | acceso abierto |
| Palabra clave: | Zika virus (ZIKV) Neural progenitor cells Heparin Cell death |
| Sumario: | The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved. |
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