AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK

The peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline (HS) can be beneficial in treating hemorrhagic shock. However, the neural mechanisms involved in this resuscitation remain unknown. the present study sought to determine the effects of selective baroreceptor denerva...

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Detalhes bibliográficos
Autores: Costa, Eloisa Ferreira de Almeida, Pedrino, Gustavo Rodrigues [UNIFESP], Lopes, Oswaldo Ubriaco [UNIFESP], Cravo, Sergio Luiz [UNIFESP]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2009
País:Brasil
Recursos:Universidade Federal de São Paulo (UNIFESP)
Repositório:Repositório Institucional da UNIFESP
Idioma:inglês
OAI Identifier:oai:repositorio.unifesp.br:11600/31691
Acesso em linha:http://dx.doi.org/10.1097/SHK.0b013e31819c3841
http://repositorio.unifesp.br/handle/11600/31691
Access Level:Acceso aberto
Palavra-chave:Hypertonic saline resuscitation
carotid baroreceptors
aortic baroreceptors
hemorrhagic shock
arterial pressure
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spelling AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCKHypertonic saline resuscitationcarotid baroreceptorsaortic baroreceptorshemorrhagic shockarterial pressureThe peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline (HS) can be beneficial in treating hemorrhagic shock. However, the neural mechanisms involved in this resuscitation remain unknown. the present study sought to determine the effects of selective baroreceptor denervation on arterial blood pressure response during HS resuscitation in rats submitted to hemorrhagic shock. Male Wistar rats (280-320 g) were anesthetized with thiopental sodium (40 mg/kg, i.v.), and the femoral artery and jugular vein were cannulated for MAP and heart rate recording and HS infusion (3 mol/L NaCl; 0.18 mL/100 g body weight, >2 min). Hemorrhagic shock was obtained by withdrawing blood over 30 min until a MAP of 60 mmHg was obtained. This level of MAP was maintained for a further 30 min through subsequent blood withdrawal or reinfusion. Next, animals were divided into selective aortic and/or carotid denervation or sham groups before infusing HS. Results showed that in the sham group (n = 12), HS infusion increased MAP to levels close to baseline (from 65 +/- 3 to 112 +/- 5 mmHg, 10 min after HS). in the aortic denervated group (n = 10), HS infusion also increased MAP (from 54 +/- 3 to 112 +/- 5 mmHg, 10 min after HS). in contrast, in the carotid denervation group (n = 8), the increase in MAP induced by HS infusion was abolished (from 53 +/- 3 to 73 +/- 12 mmHg, 10 min after HS). These results indicate that in hemorrhaged rats, HS infusion produces a pressor effect that is likely to be mediated through carotid rather than aortic baroreceptors.Universidade Federal de São Paulo, Dept Physiol, Escola Paulista Med, BR-04023060 São Paulo, BrazilUniv Oeste Paulista Presidente Prudente, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, Escola Paulista Med, BR-04023060 São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Univ Oeste Paulista Presidente Prudente2016-01-24T13:58:33Z2016-01-24T13:58:33Z2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion190-193http://dx.doi.org/10.1097/SHK.0b013e31819c3841Shock. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 2, p. 190-193, 2009.10.1097/SHK.0b013e31819c38411073-2322http://repositorio.unifesp.br/handle/11600/31691WOS:000268748400010ark:/48912/001300002vj44engShockinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPCosta, Eloisa Ferreira de AlmeidaPedrino, Gustavo Rodrigues [UNIFESP]Lopes, Oswaldo Ubriaco [UNIFESP]Cravo, Sergio Luiz [UNIFESP]2023-01-30T22:19:11Zoai:repositorio.unifesp.br:11600/31691Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-01-30T22:19:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
title AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
spellingShingle AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
Costa, Eloisa Ferreira de Almeida
Hypertonic saline resuscitation
carotid baroreceptors
aortic baroreceptors
hemorrhagic shock
arterial pressure
title_short AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
title_full AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
title_fullStr AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
title_full_unstemmed AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
title_sort AFFERENT PATHWAYS INVOLVED in CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION in RATS SUBMITTED TO HEMORRHAGIC SHOCK
dc.creator.none.fl_str_mv Costa, Eloisa Ferreira de Almeida
Pedrino, Gustavo Rodrigues [UNIFESP]
Lopes, Oswaldo Ubriaco [UNIFESP]
Cravo, Sergio Luiz [UNIFESP]
author Costa, Eloisa Ferreira de Almeida
author_facet Costa, Eloisa Ferreira de Almeida
Pedrino, Gustavo Rodrigues [UNIFESP]
Lopes, Oswaldo Ubriaco [UNIFESP]
Cravo, Sergio Luiz [UNIFESP]
author_role author
author2 Pedrino, Gustavo Rodrigues [UNIFESP]
Lopes, Oswaldo Ubriaco [UNIFESP]
Cravo, Sergio Luiz [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Univ Oeste Paulista Presidente Prudente
dc.subject.por.fl_str_mv Hypertonic saline resuscitation
carotid baroreceptors
aortic baroreceptors
hemorrhagic shock
arterial pressure
topic Hypertonic saline resuscitation
carotid baroreceptors
aortic baroreceptors
hemorrhagic shock
arterial pressure
description The peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline (HS) can be beneficial in treating hemorrhagic shock. However, the neural mechanisms involved in this resuscitation remain unknown. the present study sought to determine the effects of selective baroreceptor denervation on arterial blood pressure response during HS resuscitation in rats submitted to hemorrhagic shock. Male Wistar rats (280-320 g) were anesthetized with thiopental sodium (40 mg/kg, i.v.), and the femoral artery and jugular vein were cannulated for MAP and heart rate recording and HS infusion (3 mol/L NaCl; 0.18 mL/100 g body weight, >2 min). Hemorrhagic shock was obtained by withdrawing blood over 30 min until a MAP of 60 mmHg was obtained. This level of MAP was maintained for a further 30 min through subsequent blood withdrawal or reinfusion. Next, animals were divided into selective aortic and/or carotid denervation or sham groups before infusing HS. Results showed that in the sham group (n = 12), HS infusion increased MAP to levels close to baseline (from 65 +/- 3 to 112 +/- 5 mmHg, 10 min after HS). in the aortic denervated group (n = 10), HS infusion also increased MAP (from 54 +/- 3 to 112 +/- 5 mmHg, 10 min after HS). in contrast, in the carotid denervation group (n = 8), the increase in MAP induced by HS infusion was abolished (from 53 +/- 3 to 73 +/- 12 mmHg, 10 min after HS). These results indicate that in hemorrhaged rats, HS infusion produces a pressor effect that is likely to be mediated through carotid rather than aortic baroreceptors.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
2016-01-24T13:58:33Z
2016-01-24T13:58:33Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1097/SHK.0b013e31819c3841
Shock. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 2, p. 190-193, 2009.
10.1097/SHK.0b013e31819c3841
1073-2322
http://repositorio.unifesp.br/handle/11600/31691
WOS:000268748400010
dc.identifier.dark.fl_str_mv ark:/48912/001300002vj44
url http://dx.doi.org/10.1097/SHK.0b013e31819c3841
http://repositorio.unifesp.br/handle/11600/31691
identifier_str_mv Shock. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 2, p. 190-193, 2009.
10.1097/SHK.0b013e31819c3841
1073-2322
WOS:000268748400010
ark:/48912/001300002vj44
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Shock
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 190-193
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15,298079

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