Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy

The limitations in absorption of drugs with narrow absorption window, or those unstable in the intestinal pH or those exhibiting low solubility at high pH are primary candidates for gastroretentive drug delivery systems (GRDDS). The delivery system has been widely explored for its commercial potenti...

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Detalhes bibliográficos
Autores: Porwal, Amit, Dwivedi, Harinath, Pathak, Kamla
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Recursos:Universidade de São Paulo (USP)
Repositorio:Brazilian Journal of Pharmaceutical Sciences
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/140172
Acesso em linha:https://www.revistas.usp.br/bjps/article/view/140172
Access Level:acceso abierto
Palavra-chave:Antihypertensive drugs
Gastroretention delivery systems/absorption
Floating systems
Expanding and swelling systems
Bio/mucoadhesive systems
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spelling Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapyAntihypertensive drugsGastroretention delivery systems/absorptionFloating systemsExpanding and swelling systemsBio/mucoadhesive systemsThe limitations in absorption of drugs with narrow absorption window, or those unstable in the intestinal pH or those exhibiting low solubility at high pH are primary candidates for gastroretentive drug delivery systems (GRDDS). The delivery system has been widely explored for its commercial potential for a wide variety of therapeutic agents. GRDDS offer clinical therapeutics for acute and chronic management. Hypertension is a chronic disease that requires long term treatment and its management by patient compliant dosage forms would be clinically useful. Antihypertensives belonging to different classes have proved good candidates for the formulation of GRDDS. The review aims to discuss various GRDDS researched for antihypertensive drugs to increase the gastric residing time, bioavailability, henceforth to reduce the dose of the drug, dosing frequency and increase patient compliance. It also explores various marketed products and the patents filed/granted for GRRDS of antihypertensives. The GRDDS investigated include effervescent and non-effervescent floating drug delivery systems, swelling and expanding systems and bio/mucoadhesive systems. Many other systems that provided research platforms include high density systems, raft forming systems and osmotic delivery systems. In clinical context, wherein combination of antihypertensives is indicated, dual release delivery systems may also be explored.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/14017210.1590/s2175-97902017000300173Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00173-Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00173-Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e00173-2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/140172/135317Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessPorwal, AmitDwivedi, HarinathPathak, Kamla2017-10-27T12:44:18Zoai:revistas.usp.br:article/140172Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-10-27T12:44:18Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
title Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
spellingShingle Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
Porwal, Amit
Antihypertensive drugs
Gastroretention delivery systems/absorption
Floating systems
Expanding and swelling systems
Bio/mucoadhesive systems
title_short Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
title_full Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
title_fullStr Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
title_full_unstemmed Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
title_sort Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
dc.creator.none.fl_str_mv Porwal, Amit
Dwivedi, Harinath
Pathak, Kamla
author Porwal, Amit
author_facet Porwal, Amit
Dwivedi, Harinath
Pathak, Kamla
author_role author
author2 Dwivedi, Harinath
Pathak, Kamla
author2_role author
author
dc.subject.por.fl_str_mv Antihypertensive drugs
Gastroretention delivery systems/absorption
Floating systems
Expanding and swelling systems
Bio/mucoadhesive systems
topic Antihypertensive drugs
Gastroretention delivery systems/absorption
Floating systems
Expanding and swelling systems
Bio/mucoadhesive systems
description The limitations in absorption of drugs with narrow absorption window, or those unstable in the intestinal pH or those exhibiting low solubility at high pH are primary candidates for gastroretentive drug delivery systems (GRDDS). The delivery system has been widely explored for its commercial potential for a wide variety of therapeutic agents. GRDDS offer clinical therapeutics for acute and chronic management. Hypertension is a chronic disease that requires long term treatment and its management by patient compliant dosage forms would be clinically useful. Antihypertensives belonging to different classes have proved good candidates for the formulation of GRDDS. The review aims to discuss various GRDDS researched for antihypertensive drugs to increase the gastric residing time, bioavailability, henceforth to reduce the dose of the drug, dosing frequency and increase patient compliance. It also explores various marketed products and the patents filed/granted for GRRDS of antihypertensives. The GRDDS investigated include effervescent and non-effervescent floating drug delivery systems, swelling and expanding systems and bio/mucoadhesive systems. Many other systems that provided research platforms include high density systems, raft forming systems and osmotic delivery systems. In clinical context, wherein combination of antihypertensives is indicated, dual release delivery systems may also be explored.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/140172
10.1590/s2175-97902017000300173
url https://www.revistas.usp.br/bjps/article/view/140172
identifier_str_mv 10.1590/s2175-97902017000300173
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/140172/135317
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00173-
Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00173-
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e00173-
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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score 15,301603

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