Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.

We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in co...

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Bibliographic Details
Authors: Sardi, Janaína de Cássia Orlandi [UNESP], Gullo, Fernanda Patrícia [UNESP], Freires, Irlan Almeida, Pitangui, Nayla de Souza [UNESP], Segalla, Maicon Petrônio [UNESP], Fusco-Almeida, Ana Marisa [UNESP], Rosalen, Pedro Luiz, Regasini, Luís Octávio [UNESP], Mendes-Giannini, Maria José Soares [UNESP]
Format: article
Status:Published version
Publication Date:2016
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:English
OAI Identifier:oai:repositorio.unesp.br:11449/173724
Online Access:http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.002
http://hdl.handle.net/11449/173724
Access Level:Open access
Keyword:Antifungal
Caffeic acid
Candida albicans
Synergism
Description
Summary:We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections.

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