Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia

ß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day c...

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Detalles Bibliográficos
Autores: Carlotagudiol, Pilar Martín-dávila, Alison Freifeld, Lucía Gómez, Thomas Gottlieb, Mercè Gurguí, Fabián Herrera, Adriana Manzur, Georg Maschmeyer, Yolanda Meije, Miguel Montejo, Cristina Royo-cebrecos, Maddalena Peghin, Jesús Rodríguez-baño, Isabel Ruiz-camps, Teresa c. Sukiennik, Cristian Tebe, Jordi Carratalà, Edson Abdala, Murat Akova, Rocío Álvarez, Guillermo Maestro-de la Calle, Angela Cano, Carlos Cervera, Wanessa Trindade Clemente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal de Minas Gerais (UFMG)
Repositorio:Repositório Institucional da UFMG
Idioma:inglés
OAI Identifier:oai:repositorio.ufmg.br:1843/55695
Acceso en línea:http://hdl.handle.net/1843/55695
https://orcid.org/0000-0003-0848-3740
Access Level:acceso abierto
Palabra clave:ESBLs
Bloodstream infection
Neutropenia
beta-lactam/beta-lactamase inhibitors
Inibidores de beta-Lactamases
Sepse
Descripción
Sumario:ß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem sparing alternatives for the treatment of BSI due to ESBLs in these patients.

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