Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats
Objectives: This study evaluated if the use of a bioactive glass-ceramicbased gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/200594 |
| Acceso en línea: | http://dx.doi.org/10.1590/1678-7757-2019-0384 http://hdl.handle.net/11449/200594 |
| Access Level: | acceso abierto |
| Palabra clave: | Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
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Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in ratsBioactive glassDental pulpHydrogen peroxideTooth bleachingTooth remineralizationObjectives: This study evaluated if the use of a bioactive glass-ceramicbased gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e RestauradoraUniversidade Federal de Minas Gerais (UFMG) Faculdade de Odontologia Departamento de Odontologia RestauradoraUniversidade Federal de São Carlos (UFSCar) Departamento de Engenharia de Materiais Laboratório de Materiais VitreosUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências BásicasUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e RestauradoraUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências BásicasFAPESP: 2013/07793-6FAPESP: 2015/22996-6CNPq: 311650/2018-0Universidade Estadual Paulista (Unesp)Universidade Federal de Minas Gerais (UFMG)Universidade Federal de São Carlos (UFSCar)2020-12-12T02:10:45Z2020-12-12T02:10:45Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-10application/pdfhttp://dx.doi.org/10.1590/1678-7757-2019-0384Journal of Applied Oral Science, v. 28, p. 1-10.1678-77651678-7757http://hdl.handle.net/11449/20059410.1590/1678-7757-2019-0384S1678-775720200001004492-s2.0-85086355112S1678-77572020000100449.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCarminatti, Marina [UNESP]Benetti, Francine [UNESP]Siqueira, Renato LuizZanotto, Edgar DutraBriso, André Luiz Fraga [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]Cintra, Luciano Tavares Angelo [UNESP]2025-08-15T18:19:30Zoai:repositorio.unesp.br:11449/200594Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-08-15T18:19:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| title |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| spellingShingle |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats Carminatti, Marina [UNESP] Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
| title_short |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| title_full |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| title_fullStr |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| title_full_unstemmed |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| title_sort |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
| dc.creator.none.fl_str_mv |
Carminatti, Marina [UNESP] Benetti, Francine [UNESP] Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
| author |
Carminatti, Marina [UNESP] |
| author_facet |
Carminatti, Marina [UNESP] Benetti, Francine [UNESP] Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
| author_role |
author |
| author2 |
Benetti, Francine [UNESP] Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Cintra, Luciano Tavares Angelo [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Minas Gerais (UFMG) Universidade Federal de São Carlos (UFSCar) |
| dc.subject.por.fl_str_mv |
Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
| topic |
Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
| description |
Objectives: This study evaluated if the use of a bioactive glass-ceramicbased gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-12T02:10:45Z 2020-12-12T02:10:45Z 2020-01-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
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http://dx.doi.org/10.1590/1678-7757-2019-0384 Journal of Applied Oral Science, v. 28, p. 1-10. 1678-7765 1678-7757 http://hdl.handle.net/11449/200594 10.1590/1678-7757-2019-0384 S1678-77572020000100449 2-s2.0-85086355112 S1678-77572020000100449.pdf |
| url |
http://dx.doi.org/10.1590/1678-7757-2019-0384 http://hdl.handle.net/11449/200594 |
| identifier_str_mv |
Journal of Applied Oral Science, v. 28, p. 1-10. 1678-7765 1678-7757 10.1590/1678-7757-2019-0384 S1678-77572020000100449 2-s2.0-85086355112 S1678-77572020000100449.pdf |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Journal of Applied Oral Science |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1-10 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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