Tumorigênese Molecular Tiroideana: Implicações Para a Prática Médica
In this review we present practical aspects of thyroid molecular tumorigenesis. The most important issue is the molecular diagnosis of affected patients with RET mutations in families with medullary thyroid carcinoma and multiple endocrine neoplasia type 2. In addition, we discuss the molecular path...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2002 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/1490 |
| Acceso en línea: | http://dx.doi.org/10.1590/S0004-27302002000400009 http://repositorio.unifesp.br/handle/11600/1490 |
| Access Level: | acceso abierto |
| Palabra clave: | Thyroid tumorigenesis RET gene Thyroid carcinoma Multiple endocrine neoplasia TSH Thyroglobulin Tumorigênese tiroideana Gene RET Carcinoma de tiróide Neoplasia endócrina múltipla Tiroglobulina |
| Sumario: | In this review we present practical aspects of thyroid molecular tumorigenesis. The most important issue is the molecular diagnosis of affected patients with RET mutations in families with medullary thyroid carcinoma and multiple endocrine neoplasia type 2. In addition, we discuss the molecular pathologenesis of differentiated thyroid carcinoma, like the data on RET/PTC rearrangements in papillary carcinoma and PAX8-PPARg1 rearrangement in follicular carcinoma. Subsequently, we present gain of function mutations in thyroid nodules and finally we conclude discussing the use of messenger RNA of thyroglobulin in the follow-up of patients with differentiated thyroid cancer. |
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