The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

Background: In hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or promote their degradation are considered potential cancer treatment agents. Amino acid deprivation triggers proliferation inhibition, autophagy, and...

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Detalles Bibliográficos
Autores: Costa, Mariana do Nascimento, Silva, Thiago Aparecido [UNESP], Guimarães, Dimitrius Santiago Passos Simões Fróes, Ricci-Azevedo, Rafael, Teixeira, Felipe Roberti, Silveira, Leonardo Reis, Gomes, Marcelo Damário, Faça, Vítor Marcel, de Oliveira, Eduardo Brandt, Calado, Rodrigo T., Silva, Roberto N.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/303653
Acceso en línea:http://dx.doi.org/10.1186/s12934-024-02315-2
https://hdl.handle.net/11449/303653
Access Level:acceso abierto
Palabra clave:Cancer treatment
l-lysine α-oxidase
Leukemia
Trichoderma harzianum
Descripción
Sumario:Background: In hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or promote their degradation are considered potential cancer treatment agents. Amino acid deprivation triggers proliferation inhibition, autophagy, and programmed cell death. l-lysine, an essential amino acid, is required for tumor growth and has been investigated for its potential as a target for cancer treatment. l-lysine α-oxidase, a flavoenzyme that degrades l-lysine, has been studied for its ability to induce apoptosis and prevent cancer cell proliferation. In this study, we describe the use of l-lysine α-oxidase (LO) from the filamentous fungus Trichoderma harzianum for cancer treatment. Results: The study identified and characterized a novel LO from T. harzianum and demonstrated that the recombinant protein (rLO) has potent and selective cytotoxic effects on leukemic cells by triggering the apoptotic cascade through mitochondrial dysfunction. Conclusions: The results support future translational studies using the recombinant LO as a potential drug for the treatment of leukemia.