Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil

Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red bloo...

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Detalles Bibliográficos
Autores: Barbosa, Kledson Lopes, Lessa, Erika Elita Araújo, Soares, Margareth Alves, Souza, Walkíria de Araújo, Lins Filho, Audemário de Gusmão, Pereira, Krisley Rodrigues Lima, Chagas, Kelly Patrícia Alexandre, Araújo, Cinthya Pereira Leite Costa de, Brêda, Djana Maria de Lima, Pereira, Luciana de Andrade
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Institución:Universidade Federal de Itajubá (UNIFEI)
Repositorio:Research, Society and Development
Idioma:inglés
OAI Identifier:oai:ojs.pkp.sfu.ca:article/33555
Acceso en línea:https://rsdjournal.org/index.php/rsd/article/view/33555
Access Level:acceso abierto
Palabra clave:Aloinmunización
Anticuerpos
Antígenos
Enfermedades hematológicas
Transfusión.
Aloimunização
Anticorpos
Doenças hematológicas
Transfusão.
Alloimmunization
Antibodies
Antigens
Hematological diseases
Transfusion.
Descripción
Sumario:Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas.

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