MicroRNAs and Mammarenaviruses: modulating cellular metabolism

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Ricketsiosis. Rio de Janeiro, RJ, Brasil.

Bibliographic Details
Authors: Fernandes, Jorlan, Miranda, Renan Lyra, Lemos, Elba Regina Sampaio de, Guterres, Alexandro
Format: article
Status:Published version
Publication Date:2020
Country:Brasil
Institution:Fundação Oswaldo Cruz (FIOCRUZ)
Repository:Repositório Institucional da FIOCRUZ (ARCA)
Language:English
OAI Identifier:oai:arca.fiocruz.br:icict/45438
Online Access:https://arca.fiocruz.br/handle/icict/45438
Access Level:Open access
Keyword:MicroRNAs
Erros iInatos do Metabolismo dos Aminoácidos
Metabolismo celular
Arenaviridae
Metabolismo de cofatores e vitaminas
Amino acid metabolism
Cellular metabolism
Mammarenaviruses
Metabolism of cofactors and vitamins
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dc.title.none.fl_str_mv MicroRNAs and Mammarenaviruses: modulating cellular metabolism
title MicroRNAs and Mammarenaviruses: modulating cellular metabolism
spellingShingle MicroRNAs and Mammarenaviruses: modulating cellular metabolism
Fernandes, Jorlan
MicroRNAs
Erros iInatos do Metabolismo dos Aminoácidos
Metabolismo celular
Arenaviridae
Metabolismo de cofatores e vitaminas
Amino acid metabolism
Cellular metabolism
Mammarenaviruses
Metabolism of cofactors and vitamins
MicroRNAs
Arenaviridae
title_short MicroRNAs and Mammarenaviruses: modulating cellular metabolism
title_full MicroRNAs and Mammarenaviruses: modulating cellular metabolism
title_fullStr MicroRNAs and Mammarenaviruses: modulating cellular metabolism
title_full_unstemmed MicroRNAs and Mammarenaviruses: modulating cellular metabolism
title_sort MicroRNAs and Mammarenaviruses: modulating cellular metabolism
dc.creator.none.fl_str_mv Fernandes, Jorlan
Miranda, Renan Lyra
Lemos, Elba Regina Sampaio de
Guterres, Alexandro
author Fernandes, Jorlan
author_facet Fernandes, Jorlan
Miranda, Renan Lyra
Lemos, Elba Regina Sampaio de
Guterres, Alexandro
author_role author
author2 Miranda, Renan Lyra
Lemos, Elba Regina Sampaio de
Guterres, Alexandro
author2_role author
author
author
dc.subject.other.none.fl_str_mv MicroRNAs
Erros iInatos do Metabolismo dos Aminoácidos
Metabolismo celular
Arenaviridae
Metabolismo de cofatores e vitaminas
topic MicroRNAs
Erros iInatos do Metabolismo dos Aminoácidos
Metabolismo celular
Arenaviridae
Metabolismo de cofatores e vitaminas
Amino acid metabolism
Cellular metabolism
Mammarenaviruses
Metabolism of cofactors and vitamins
MicroRNAs
Arenaviridae
dc.subject.en.none.fl_str_mv Amino acid metabolism
Cellular metabolism
Mammarenaviruses
Metabolism of cofactors and vitamins
MicroRNAs
dc.subject.decs.none.fl_str_mv Arenaviridae
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Ricketsiosis. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-12-27T18:07:05Z
dc.date.available.fl_str_mv 2020-12-27T18:07:05Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Jorlan et al. MicroRNAs and Mammarenaraviruses: Modulating Cellular Metabolism. Cells, v. 9, p. 1-18, 2020.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/45438
dc.identifier.issn.none.fl_str_mv 2073-4409
dc.identifier.doi.none.fl_str_mv 10.3390/cells9112525
identifier_str_mv FERNANDES, Jorlan et al. MicroRNAs and Mammarenaraviruses: Modulating Cellular Metabolism. Cells, v. 9, p. 1-18, 2020.
2073-4409
10.3390/cells9112525
url https://arca.fiocruz.br/handle/icict/45438
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2020-12-27T18:07:05Z2020-12-27T18:07:05Z2020FERNANDES, Jorlan et al. MicroRNAs and Mammarenaraviruses: Modulating Cellular Metabolism. Cells, v. 9, p. 1-18, 2020.2073-4409https://arca.fiocruz.br/handle/icict/4543810.3390/cells9112525engMDPIMicroRNAsErros iInatos do Metabolismo dos AminoácidosMetabolismo celularArenaviridaeMetabolismo de cofatores e vitaminasAmino acid metabolismCellular metabolismMammarenavirusesMetabolism of cofactors and vitaminsMicroRNAsArenaviridaeMicroRNAs and Mammarenaviruses: modulating cellular metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Ricketsiosis. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Laboratório de Interações Neuroquímicas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Ricketsiosis. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Ricketsiosis. Rio de Janeiro, RJ, Brasil.Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during virus infection are different between and within New World and Old World viral infections. Viruses rely exclusively on the host cellular machinery to translate their genome, and therefore to replicate and propagate. miRNAs are the crucial factor in diverse biological processes such as antiviral defense, oncogenesis, and cell development. The viral infection can exert a profound impact on the cellular miRNA expression profile, and numerous RNA viruses have been reported to interact directly with cellular miRNAs and/or to use these miRNAs to augment their replication potential. Our present study indicates that mammarenavirus infection induces metabolic reprogramming of host cells, probably manipulating cellular microRNAs. A number of metabolic pathways, including valine, leucine, and isoleucine biosynthesis, d-Glutamine and d-glutamate metabolism, thiamine metabolism, and pools of several amino acids were impacted by the predicted miRNAs that would no longer regulate these pathways. A deeper understanding of mechanisms by which mammarenaviruses handle these signaling pathways is critical for understanding the virus/host interactions and potential diagnostic and therapeutic targets, through the inhibition of specific pathologic metabolic pathways.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZFernandes, JorlanMiranda, Renan LyraLemos, Elba Regina Sampaio deGuterres, AlexandroLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/89008d80-8ebb-4e78-a2cb-6dfb6d63105d/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALElaRSLemos_alexandre Guterres_etal_IOC_2020.pdfElaRSLemos_alexandre Guterres_etal_IOC_2020.pdfapplication/pdf1891335https://arca.fiocruz.br/bitstreams/aa324f21-6d26-4641-a9cb-1ca881db7a0c/download4ded5c2ba3b80acf0e78b8a12dac34b2MD52trueAnonymousREADTEXTElaRSLemos_alexandre Guterres_etal_IOC_2020.pdf.txtElaRSLemos_alexandre Guterres_etal_IOC_2020.pdf.txtExtracted texttext/plain82519https://arca.fiocruz.br/bitstreams/177f0590-a843-4eee-ac6e-4785ef040408/download11925e82afca900c4cdd04d5e0a48d5bMD59falseAnonymousREADTHUMBNAILElaRSLemos_alexandre Guterres_etal_IOC_2020.pdf.jpgElaRSLemos_alexandre Guterres_etal_IOC_2020.pdf.jpgGenerated Thumbnailimage/jpeg39924https://arca.fiocruz.br/bitstreams/30c175c5-4644-4c64-96f4-d960e9f6bfab/download5ba7c79d68fe5050530b13613b0267d5MD510falseAnonymousREADicict/454382025-12-10 15:09:39.984open.accessoai:arca.fiocruz.br:icict/45438https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T18:09:39Repositório Institucional da FIOCRUZ (ARCA) - 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