Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial

This study aimed to evaluate the efficacy of non-invasive and micro-invasive treatments on the arrest of occlusal enamel carious lesions in erupting permanent molars. This two-arm randomized clinical trial included 27 subjects, aged 5–11 years, with 64 erupting permanent molars presenting active occ...

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Autores: Rodrigues, Jonas de Almeida, Santos, Nicole Marchioro dos, Azevedo, Claudia Britto, Haas, Alex Nogueira, Lenzi, Tathiane Larissa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/225493
Acceso en línea:http://hdl.handle.net/10183/225493
Access Level:acceso abierto
Palabra clave:Ensaio clínico
Cárie dentária
Dente molar
Erupção dentária
Fluoretos
Clinical Trial
Dental Caries
Molar
Tooth Eruption
Fluorides
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spelling 2021-08-10T04:32:21Z20211806-8324http://hdl.handle.net/10183/225493001129869This study aimed to evaluate the efficacy of non-invasive and micro-invasive treatments on the arrest of occlusal enamel carious lesions in erupting permanent molars. This two-arm randomized clinical trial included 27 subjects, aged 5–11 years, with 64 erupting permanent molars presenting active occlusal enamel carious lesions (as assessed by the International Caries Detection and Assessment System [ICDAS]; scores 1–3). The sample was randomly assigned into two treatment groups: 1) resin-modified glass ionomer cement sealant (Clinpro XT Varnish; 3M ESPE) and 2) 4-week topical fluoride varnish application (Duraphat; Colgate). All children and parents received oral hygiene and dietary instructions. Teeth were evaluated at baseline and 3, 6, 9, and 12 months regarding the eruption stage, biofilm accumulation, as well as severity and activity of the carious lesions. The Kaplan-Meier method was used to evaluate the survival estimates for inactivation of the carious lesions for both treatment groups. Multivariate Cox regression models with shared frailty were performed to identify factors associated with the outcome (p < 0.05). After 12 months, 22% and 3% of the lesions treated with topical fluoride varnish and sealant, respectively remained active. The adjusted model demonstrated that younger children had a higher probability of active enamel carious lesions arresting (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.22-0.78; p=0.01). However, the probability of active enamel carious lesions arresting after sealant application was 8.85 times higher compared with fluoride varnish applications (p=0.01). Sealing is a more effective approach than fluoride varnish for arresting occlusal enamel carious lesions in erupting permanent molars.application/pdfengBrazilian oral research. São Paulo. Vol. 35 (2021), p. 1-9, e058Ensaio clínicoCárie dentáriaDente molarErupção dentáriaFluoretosClinical TrialDental CariesMolarTooth EruptionFluoridesNon-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trialinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSRodrigues, Jonas de AlmeidaSantos, Nicole Marchioro dosAzevedo, Claudia BrittoHaas, Alex NogueiraLenzi, Tathiane LarissaTEXT001129869.pdf.txt001129869.pdf.txtExtracted Texttext/plain32434http://www.lume.ufrgs.br/bitstream/10183/225493/2/001129869.pdf.txtc5b8d3e80935271ed8ef90e0e913c435MD52ORIGINAL001129869.pdfTexto completo (inglês)application/pdf278969http://www.lume.ufrgs.br/bitstream/10183/225493/1/001129869.pdf072ab093308ce01dcb94a791b12a3f62MD5110183/2254932022-11-11 05:48:54.047646oai:www.lume.ufrgs.br:10183/225493Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2022-11-11T07:48:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
title Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
spellingShingle Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
Rodrigues, Jonas de Almeida
Ensaio clínico
Cárie dentária
Dente molar
Erupção dentária
Fluoretos
Clinical Trial
Dental Caries
Molar
Tooth Eruption
Fluorides
title_short Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
title_full Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
title_fullStr Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
title_full_unstemmed Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
title_sort Non-invasive and micro-invasive treatments to arrest active occlusal carious lesions in erupting permanent molars : a randomized clinical trial
dc.creator.none.fl_str_mv Rodrigues, Jonas de Almeida
Santos, Nicole Marchioro dos
Azevedo, Claudia Britto
Haas, Alex Nogueira
Lenzi, Tathiane Larissa
author Rodrigues, Jonas de Almeida
author_facet Rodrigues, Jonas de Almeida
Santos, Nicole Marchioro dos
Azevedo, Claudia Britto
Haas, Alex Nogueira
Lenzi, Tathiane Larissa
author_role author
author2 Santos, Nicole Marchioro dos
Azevedo, Claudia Britto
Haas, Alex Nogueira
Lenzi, Tathiane Larissa
author2_role author
author
author
author
dc.subject.por.fl_str_mv Ensaio clínico
Cárie dentária
Dente molar
Erupção dentária
Fluoretos
topic Ensaio clínico
Cárie dentária
Dente molar
Erupção dentária
Fluoretos
Clinical Trial
Dental Caries
Molar
Tooth Eruption
Fluorides
dc.subject.eng.fl_str_mv Clinical Trial
Dental Caries
Molar
Tooth Eruption
Fluorides
description This study aimed to evaluate the efficacy of non-invasive and micro-invasive treatments on the arrest of occlusal enamel carious lesions in erupting permanent molars. This two-arm randomized clinical trial included 27 subjects, aged 5–11 years, with 64 erupting permanent molars presenting active occlusal enamel carious lesions (as assessed by the International Caries Detection and Assessment System [ICDAS]; scores 1–3). The sample was randomly assigned into two treatment groups: 1) resin-modified glass ionomer cement sealant (Clinpro XT Varnish; 3M ESPE) and 2) 4-week topical fluoride varnish application (Duraphat; Colgate). All children and parents received oral hygiene and dietary instructions. Teeth were evaluated at baseline and 3, 6, 9, and 12 months regarding the eruption stage, biofilm accumulation, as well as severity and activity of the carious lesions. The Kaplan-Meier method was used to evaluate the survival estimates for inactivation of the carious lesions for both treatment groups. Multivariate Cox regression models with shared frailty were performed to identify factors associated with the outcome (p < 0.05). After 12 months, 22% and 3% of the lesions treated with topical fluoride varnish and sealant, respectively remained active. The adjusted model demonstrated that younger children had a higher probability of active enamel carious lesions arresting (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.22-0.78; p=0.01). However, the probability of active enamel carious lesions arresting after sealant application was 8.85 times higher compared with fluoride varnish applications (p=0.01). Sealing is a more effective approach than fluoride varnish for arresting occlusal enamel carious lesions in erupting permanent molars.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-10T04:32:21Z
dc.date.issued.fl_str_mv 2021
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/225493
dc.identifier.issn.pt_BR.fl_str_mv 1806-8324
dc.identifier.nrb.pt_BR.fl_str_mv 001129869
identifier_str_mv 1806-8324
001129869
url http://hdl.handle.net/10183/225493
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Brazilian oral research. São Paulo. Vol. 35 (2021), p. 1-9, e058
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
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