A pneumonia outbreak associated with a new coronavirus of probable bat origin

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Her...

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Detalles Bibliográficos
Autores: Zhou, Peng, Yang, Xing-Lou, Wang, Xian-Guang, Hu, Ben, Zhang, Lei, Zhang, Wei, Si, Hao-Rui, Zhu, Yan, Li, Bei, Huang, Chao-Lin, Chen, Hui-Dong, Chen, Jing, Luo, Yun, Guo, Hua, Jiang, Ren-Di, Liu, Mei-Qin, Chen, Ying, Shen, Xu-Rui, Wang, Xi, Zheng, Xiao-Shuang, Zhao, Kai, Chen, Quan-Jiao, Deng, Fei, Liu, Lin-Lin, Yan, Bing, Zhan, Fa-Xian, Wang, Yan-Yi, Xiao, Geng-Fu, Shi, Zheng-Li
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Federal de Lavras (UFLA)
Repositorio:Repositório Institucional da UFLA
Idioma:inglés
OAI Identifier:oai:repositorio.ufla.br:1/39411
Acceso en línea:https://repositorio.ufla.br/handle/1/39411
Access Level:acceso abierto
Palabra clave:Coronavirus
Severe acute respiratory syndrome
Pathogenic virus
Síndrome respiratória aguda grave
Vírus patogênicos
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network_name_str Brasil
repository_id_str
dc.title.pt_BR.fl_str_mv A pneumonia outbreak associated with a new coronavirus of probable bat origin
title A pneumonia outbreak associated with a new coronavirus of probable bat origin
spellingShingle A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, Peng
Coronavirus
Severe acute respiratory syndrome
Pathogenic virus
Síndrome respiratória aguda grave
Vírus patogênicos
title_short A pneumonia outbreak associated with a new coronavirus of probable bat origin
title_full A pneumonia outbreak associated with a new coronavirus of probable bat origin
title_fullStr A pneumonia outbreak associated with a new coronavirus of probable bat origin
title_full_unstemmed A pneumonia outbreak associated with a new coronavirus of probable bat origin
title_sort A pneumonia outbreak associated with a new coronavirus of probable bat origin
dc.creator.none.fl_str_mv Zhou, Peng
Yang, Xing-Lou
Wang, Xian-Guang
Hu, Ben
Zhang, Lei
Zhang, Wei
Si, Hao-Rui
Zhu, Yan
Li, Bei
Huang, Chao-Lin
Chen, Hui-Dong
Chen, Jing
Luo, Yun
Guo, Hua
Jiang, Ren-Di
Liu, Mei-Qin
Chen, Ying
Shen, Xu-Rui
Wang, Xi
Zheng, Xiao-Shuang
Zhao, Kai
Chen, Quan-Jiao
Deng, Fei
Liu, Lin-Lin
Yan, Bing
Zhan, Fa-Xian
Wang, Yan-Yi
Xiao, Geng-Fu
Shi, Zheng-Li
author Zhou, Peng
author_facet Zhou, Peng
Yang, Xing-Lou
Wang, Xian-Guang
Hu, Ben
Zhang, Lei
Zhang, Wei
Si, Hao-Rui
Zhu, Yan
Li, Bei
Huang, Chao-Lin
Chen, Hui-Dong
Chen, Jing
Luo, Yun
Guo, Hua
Jiang, Ren-Di
Liu, Mei-Qin
Chen, Ying
Shen, Xu-Rui
Wang, Xi
Zheng, Xiao-Shuang
Zhao, Kai
Chen, Quan-Jiao
Deng, Fei
Liu, Lin-Lin
Yan, Bing
Zhan, Fa-Xian
Wang, Yan-Yi
Xiao, Geng-Fu
Shi, Zheng-Li
author_role author
author2 Yang, Xing-Lou
Wang, Xian-Guang
Hu, Ben
Zhang, Lei
Zhang, Wei
Si, Hao-Rui
Zhu, Yan
Li, Bei
Huang, Chao-Lin
Chen, Hui-Dong
Chen, Jing
Luo, Yun
Guo, Hua
Jiang, Ren-Di
Liu, Mei-Qin
Chen, Ying
Shen, Xu-Rui
Wang, Xi
Zheng, Xiao-Shuang
Zhao, Kai
Chen, Quan-Jiao
Deng, Fei
Liu, Lin-Lin
Yan, Bing
Zhan, Fa-Xian
Wang, Yan-Yi
Xiao, Geng-Fu
Shi, Zheng-Li
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.por.fl_str_mv Coronavirus
Severe acute respiratory syndrome
Pathogenic virus
Síndrome respiratória aguda grave
Vírus patogênicos
topic Coronavirus
Severe acute respiratory syndrome
Pathogenic virus
Síndrome respiratória aguda grave
Vírus patogênicos
description Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-03-26T11:55:17Z
dc.date.available.fl_str_mv 2020-03-26T11:55:17Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020.
dc.identifier.uri.fl_str_mv https://repositorio.ufla.br/handle/1/39411
identifier_str_mv ZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020.
url https://repositorio.ufla.br/handle/1/39411
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.pt_BR.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFLA
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instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
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spelling 2020-03-26T11:55:17Z2020-03-26T11:55:17Z2020ZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020.https://repositorio.ufla.br/handle/1/39411Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.Springer NatureAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessNaturereponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLACoronavirusSevere acute respiratory syndromePathogenic virusSíndrome respiratória aguda graveVírus patogênicosA pneumonia outbreak associated with a new coronavirus of probable bat origininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengZhou, PengYang, Xing-LouWang, Xian-GuangHu, BenZhang, LeiZhang, WeiSi, Hao-RuiZhu, YanLi, BeiHuang, Chao-LinChen, Hui-DongChen, JingLuo, YunGuo, HuaJiang, Ren-DiLiu, Mei-QinChen, YingShen, Xu-RuiWang, XiZheng, Xiao-ShuangZhao, KaiChen, Quan-JiaoDeng, FeiLiu, Lin-LinYan, BingZhan, Fa-XianWang, Yan-YiXiao, Geng-FuShi, Zheng-LiORIGINALARTIGO_A pneumonia outbreak associated with a new coronavirus of probable bat origin.pdfARTIGO_A pneumonia outbreak associated with a new coronavirus of probable bat origin.pdfapplication/pdf10866187https://repositorio.ufla.br/bitstreams/3b763e08-7c81-47f4-822c-cc9b0c46ddc2/download298a04bdebb64b9910315b1f5d96e167MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8907https://repositorio.ufla.br/bitstreams/56784822-4ff3-4a55-95d4-1aa5d37f816c/downloadc07b6daef3dbee864bf87e6aa836cde2MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-8953https://repositorio.ufla.br/bitstreams/90ccef11-b004-4945-869f-8775f1f30d93/download760884c1e72224de569e74f79eb87ce3MD53falseAnonymousREAD1/394112025-07-17 12:29:29.625http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accessoai:repositorio.ufla.br:1/39411https://repositorio.ufla.brRepositório InstitucionalPUBhttps://repositorio.ufla.br/server/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2025-07-17T15:29:29Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)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