Prevalência de deficiência hipofisária na hemorragia subaracnóidea aneurismática
Introduction: Pituitary dysfunction is a condition that has been observed frequently in patients victims of aneurysmal subarachnoid haemorrhage (aSAH) and its prevalence has been little studied in the literature. Objective: The aim of this study was to determine the prevalence of hypopituitarism at...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Federal de Minas Gerais (UFMG) |
| Repositorio: | Repositório Institucional da UFMG |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufmg.br:1843/BUBD-AW6FZ8 |
| Acceso en línea: | http://hdl.handle.net/1843/BUBD-AW6FZ8 |
| Access Level: | acceso abierto |
| Palabra clave: | Hemorragia Subaracnóidea Aneurisma Intracraniano Hormônios Adeno-Hipofisários Hipopituitarismo Hemorragia subaracnóidea Aneurisma intracraniano Hipopituitarismo/epidemiologia Medicina Hormônios adeno-hipofisários Estudos prospectivos |
| Sumario: | Introduction: Pituitary dysfunction is a condition that has been observed frequently in patients victims of aneurysmal subarachnoid haemorrhage (aSAH) and its prevalence has been little studied in the literature. Objective: The aim of this study was to determine the prevalence of hypopituitarism at the acute stage of aSAH as well as the chronic stage, at least 1 year after bleeding, to assess its correlation with clinical features of the studied population. Patients Methods: The prospective cohort study that evaluated patients admitted between June 2009 and October 2011 with a diagnosis of aSAH. Clinical and endocrine assessment was performed at the acute stage after hospital admission and before treatment at a mean of 7.5 (SD ± 3.8) days following aSAH. Another follow up was performed at a mean of 25.5 months (range: 12 55 months) after the bleeding. Results: A total of 92 patients were analyzed and 68 (73.9%) were followed in both acute and chronic phases. Dysfunction in the acute phase was lower among yonger compared to those without dysfunction (p < 0.05). The prevalence of dysfunction in the acute phase was higher among those with hydrocephalus on admission CT (57.9%) than among those without it (p < 0.05). At the chronic phase there was an association between pituitary dysfunction and Hunt & Hess scale > 2 (p < 0.05). Conclusions: There is not enough evidence to incorporate routine endocrinological evaluation to patients victims of SAH, but we should always keep this differential diagnosis in mind when conducting long-term assessments of this population. |
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