Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols
In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2009 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/71087 |
| Acceso en línea: | http://dx.doi.org/10.1017/S0007114508066774 http://hdl.handle.net/11449/71087 |
| Access Level: | acceso abierto |
| Palabra clave: | Body fat Fructose Insulin sensitivity Metabolic syndrome cholesterol drinking water fructose high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol age distribution animal experiment animal model body fat carbohydrate intake cholesterol blood level controlled study experimental rat food analysis food composition fructose metabolism glucose tolerance hypertriglyceridemia insulin sensitivity lipid blood level male metabolic balance metabolic syndrome X nonhuman rat triacylglycerol blood level Wistar rat Animals Blood Glucose Cholesterol Disease Models, Animal Glucose Tolerance Test Insulin Insulin Resistance Male Metabolic Syndrome X Rats Rats, Wistar Weight Gain Animalia Rattus Rattus norvegicus Rodentia |
| Sumario: | In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent chow (Labina, Purina) and a fructose group (F1; n 6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2; n 6) was fed on a balanced diet (AIN-93G) and a fructose group (F2; n 6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3; n 6) was fed on the AIN-93G diet and a fructose group (F3; n 6) was fed on a 60 % fructose diet. After 4-8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0.05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water. |
|---|