Administração tópica de cloridrato de hidralazina na viabilidade de retalho cutâneo randômico em ratos
PURPOSE: Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats. METHODS: Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10X4 cm. The animals...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Universidade Federal de São Paulo (UNIFESP) |
| Repositorio: | Repositório Institucional da UNIFESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/2473 |
| Acceso en línea: | http://dx.doi.org/10.1590/S0102-86502005000200011 http://repositorio.unifesp.br/handle/11600/2473 |
| Access Level: | acceso abierto |
| Palabra clave: | Surgical Flaps Hydralazine Iontophorese Rats Retalhos Cirúrgicos Hidralazina Iontoforese Ratos |
| Sumario: | PURPOSE: Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats. METHODS: Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10X4 cm. The animals from group 1 was utilized as control, in group 2 was submitted to direct current o 4mA-20' immediately after the surgery and on the two subsequent days. In group 3 the stimulation eletric simulation with hydralazine hydrochloride. In group 4 iontophorese with hydralazine hydrochloride 4mA-20'. The analysis of the results was made on the seventh day post operative and interpreted with test non parametric of Kruskal-Wallis. RESULTS: and the necrotic area stayed fixed in: group 1= 45%; group 2= 39%; group 3= 46% and group 4= 41%, being the statistical analysis did not evedenced any significant. CONCLUSION: The hydralazine hydrochloride when taken for iontophorese was not efficacious in reduce the necrotic area. |
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