Preparative Isolation of Antimycobacterial Shoreic Acid from Cabralea canjerana by High Speed Countercurrent Chromatography

High speed countercurrent chromatography (HSCCC) was used to isolate the dammarane type triterpene shoreic acid from the dichloromethane extract of leaves of Cabralea canjerana, which showed activity against Mycobacterium tuberculosis. A preparative scale-up of the process was also developed.

Detalles Bibliográficos
Autores: Leitão, Gilda Guimarães, Abreu, Lisandra Ferreira de, Costa, Fernanda das Neves, Brum, Thiago Braga, Soares, Daniela Fernandes Ramos, Silva, Pedro Eduardo Almeida da, Lourenço, Maria Cristina da Silva, Leitão, Suzana Guimarães
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Brasil
Institución:Universidade Federal do Rio Grande (FURG)
Repositorio:Repositório Institucional da FURG (RI FURG)
Idioma:inglés
OAI Identifier:oai:repositorio.furg.br:1/7182
Acceso en línea:http://repositorio.furg.br/handle/1/7182
Access Level:acceso abierto
Palabra clave:High-speed countercurrent chromatography
HSCCC
Cabralea canjerana
Tuberculosis
Antimycobacterial activity
Meliaceae
Descripción
Sumario:High speed countercurrent chromatography (HSCCC) was used to isolate the dammarane type triterpene shoreic acid from the dichloromethane extract of leaves of Cabralea canjerana, which showed activity against Mycobacterium tuberculosis. A preparative scale-up of the process was also developed.

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