Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 p...
| Autores: | , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2017 |
| País: | Brasil |
| Recursos: | Universidade Federal do Rio Grande do Norte (UFRN) |
| Repositório: | Repositório Institucional da UFRN |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.ufrn.br:123456789/29575 |
| Acesso em linha: | https://repositorio.ufrn.br/jspui/handle/123456789/29575 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cancer/testis Cancer antigens Biomarkers Prognosis |
| Resumo: | Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma |
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