Yellow fever virus: historical and current issues regarding recent epidemics and vaccination in Brazil

Yellow fever has been recently described in nonurban areas of Brazil despite 80 years of commercial vaccine use. Although the disease does not spread fear in the general population as it did in the past, yellow fever virus continues to cause many cases of severe disease. Persistence of the virus in...

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Detalles Bibliográficos
Autores: Ishak, Ricardo, Ishak, Marluísa de Oliveira Guimarães, Vallinoto, Antonio Carlos Rosário, Pinheiro, Francisco de Paula
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Institución:Instituto Evandro Chagas (IEC)
Repositorio:Repositório Digital do Instituto Evandro Chagas (Patuá)
Idioma:inglés
OAI Identifier:oai:patua.iec.gov.br:iec/3994
Acceso en línea:https://patua.iec.gov.br/handle/iec/3994
Access Level:acceso abierto
Palabra clave:Febre Amarela
Vacina contra Febre Amarela
Vírus da Febre Amarela / patogenicidade
Prevalência
Monitoramento Epidemiológico
Descripción
Sumario:Yellow fever has been recently described in nonurban areas of Brazil despite 80 years of commercial vaccine use. Although the disease does not spread fear in the general population as it did in the past, yellow fever virus continues to cause many cases of severe disease. Persistence of the virus in the host is a new mechanism to be considered in the pathology of the disease. Immunization with a fractional dose of vaccine during emergency situations needs to be evaluated for antibody duration, and new and improved vaccines should be considered.