Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial

There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospit...

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Autores: Flores, Josani Silva, Ziegler, Bruna, Ferreira, Daiane Nicoli Silvello dos Santos, Dalcin, Paulo de Tarso Roth
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/282878
Acceso en línea:http://hdl.handle.net/10183/282878
Access Level:acceso abierto
Palabra clave:Fibrose cística
Adulto
Exercício físico
Exacerbação dos sintomas
Hospitalização
Cystic fibrosis
Adults
Physical exercise
Pulmonary exacerbation
Hospitalization
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spelling 2024-12-25T06:52:23Z20230100-879Xhttp://hdl.handle.net/10183/282878001216591There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospitalized for pulmonary exacerbation. In this randomized controlled trial, 19 patients were included in the intervention group and 15 in the control group. The intervention group underwent an early rehabilitation program for 14 days after admission. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured. In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention. In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto. Vol. 56 (2023), e12752, 10 p.Fibrose císticaAdultoExercício físicoExacerbação dos sintomasHospitalizaçãoCystic fibrosisAdultsPhysical exercisePulmonary exacerbationHospitalizationEffects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trialinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSFlores, Josani SilvaZiegler, BrunaFerreira, Daiane Nicoli Silvello dos SantosDalcin, Paulo de Tarso RothTEXT001216591.pdf.txt001216591.pdf.txtExtracted Texttext/plain35408http://www.lume.ufrgs.br/bitstream/10183/282878/2/001216591.pdf.txtc5e05574446ac2baa182007f1732df72MD52ORIGINAL001216591.pdfTexto completo (inglês)application/pdf688214http://www.lume.ufrgs.br/bitstream/10183/282878/1/001216591.pdf3d30a2a40f0148ac3af378445eb946feMD5110183/2828782024-12-26 07:50:21.360309oai:www.lume.ufrgs.br:10183/282878Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2024-12-26T09:50:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
title Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
spellingShingle Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
Flores, Josani Silva
Fibrose cística
Adulto
Exercício físico
Exacerbação dos sintomas
Hospitalização
Cystic fibrosis
Adults
Physical exercise
Pulmonary exacerbation
Hospitalization
title_short Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
title_full Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
title_fullStr Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
title_full_unstemmed Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
title_sort Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization : a randomized clinical trial
dc.creator.none.fl_str_mv Flores, Josani Silva
Ziegler, Bruna
Ferreira, Daiane Nicoli Silvello dos Santos
Dalcin, Paulo de Tarso Roth
author Flores, Josani Silva
author_facet Flores, Josani Silva
Ziegler, Bruna
Ferreira, Daiane Nicoli Silvello dos Santos
Dalcin, Paulo de Tarso Roth
author_role author
author2 Ziegler, Bruna
Ferreira, Daiane Nicoli Silvello dos Santos
Dalcin, Paulo de Tarso Roth
author2_role author
author
author
dc.subject.por.fl_str_mv Fibrose cística
Adulto
Exercício físico
Exacerbação dos sintomas
Hospitalização
topic Fibrose cística
Adulto
Exercício físico
Exacerbação dos sintomas
Hospitalização
Cystic fibrosis
Adults
Physical exercise
Pulmonary exacerbation
Hospitalization
dc.subject.eng.fl_str_mv Cystic fibrosis
Adults
Physical exercise
Pulmonary exacerbation
Hospitalization
description There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) with pulmonary exacerbation. This study aimed to evaluate the effects of an early rehabilitation program on lung function, muscle strength, inflammatory markers, and quality of life in adults with CF hospitalized for pulmonary exacerbation. In this randomized controlled trial, 19 patients were included in the intervention group and 15 in the control group. The intervention group underwent an early rehabilitation program for 14 days after admission. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured. In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention. In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life.
publishDate 2023
dc.date.issued.fl_str_mv 2023
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research. Ribeirão Preto. Vol. 56 (2023), e12752, 10 p.
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reponame_str Repositório Institucional da UFRGS
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