The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Brasil |
| Recursos: | Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
| Repositorio: | Revista Brasileira de Cancerologia (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:rbc.inca.gov.br:article/2852 |
| Acesso em linha: | https://rbc.inca.gov.br/index.php/revista/article/view/2852 |
| Access Level: | acceso abierto |
| Palavra-chave: | Apoptose Oncogenes Genes Supressores de Tumor Carcinogênese Apoptosis Tumor Suppressor Genes Carcinogenesis |
| Resumo: | Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications. |
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