Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related

Texto completo: acesso restrito. p. 888-896

Detalles Bibliográficos
Autores: Moschioni, Monica, Donati, Claudio, Muzzi, Alessandro, Hanage, William P, Reis, Joice Neves, Normark, Staffan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Brasil
Institución:Universidade Federal da Bahia (UFBA)
Repositorio:Repositório Institucional da UFBA
Idioma:inglés
OAI Identifier:oai:repositorio.ufba.br:ri/14417
Acceso en línea:http://repositorio.ufba.br/ri/handle/ri/14417
Access Level:acceso abierto
Palabra clave:Streptococcus
Pneumonia
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dc.title.pt_BR.fl_str_mv Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
dc.title.alternative.pt_BR.fl_str_mv Journal of Infectious Diseases
title Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
spellingShingle Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
Moschioni, Monica
Streptococcus
Pneumonia
title_short Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
title_full Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
title_fullStr Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
title_full_unstemmed Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
title_sort Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
dc.creator.none.fl_str_mv Moschioni, Monica
Donati, Claudio
Muzzi, Alessandro
Hanage, William P
Reis, Joice Neves
Normark, Staffan
Moschioni, Monica
Donati, Claudio
Muzzi, Alessandro
Hanage, William P
Reis, Joice Neves
Normark, Staffan
author Moschioni, Monica
author_facet Moschioni, Monica
Donati, Claudio
Muzzi, Alessandro
Hanage, William P
Reis, Joice Neves
Normark, Staffan
author_role author
author2 Donati, Claudio
Muzzi, Alessandro
Hanage, William P
Reis, Joice Neves
Normark, Staffan
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv Streptococcus
Pneumonia
topic Streptococcus
Pneumonia
description Texto completo: acesso restrito. p. 888-896
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-01-21T21:10:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14417
dc.identifier.issn.none.fl_str_mv 0022-1899
dc.identifier.number.pt_BR.fl_str_mv v. 197, n. 6
identifier_str_mv 0022-1899
v. 197, n. 6
url http://repositorio.ufba.br/ri/handle/ri/14417
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1086/528375
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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spelling 2014-01-21T21:10:07Z20080022-1899http://repositorio.ufba.br/ri/handle/ri/14417v. 197, n. 6Texto completo: acesso restrito. p. 888-896Background Pilus components of Streptococcus pneumoniae encoded by rlrA were recently shown to elicit protection in an animal model of infection. Limited data are available on the prevalence of the rlrA operon in pneumococci; therefore, we investigated its distribution and its antigenic variation among disease-causing strains MethodsThe prevalence of rlrA and its association with serotype and genotype were evaluated in a global panel of 424 pneumococci isolates (including the 26 drug-resistant clones described by the Pneumococcal Molecular Epidemiology Network) ResultsThe rlrA islet was found in 130 isolates (30.6%) of the defined collection. Sequence alignment of 15 rlrA islets defined the presence of 3 clade types, with an overall homology of 88%–92%. The presence or absence of a pilus-encoding operon correlated with S. pneumoniae genotype (P<.001), as determined by multilocus sequence typing, and not with serotype. Further investigation identified a positive trend of rlrA occurrence among antimicrobial-resistant pneumococci ConclusionsOn the basis of S. pneumoniae genotype, it is possible to predict the incidence of the rlrA pilus operon in a collection of pneumococcal isolates. This will facilitate the development of a protein vaccineSubmitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-11T14:42:21Z No. of bitstreams: 1 10.1086528375.pdf: 3698045 bytes, checksum: bd8325c47814f7a0d9310921fae58372 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-21T21:10:06Z (GMT) No. of bitstreams: 1 10.1086528375.pdf: 3698045 bytes, checksum: bd8325c47814f7a0d9310921fae58372 (MD5)Made available in DSpace on 2014-01-21T21:10:07Z (GMT). 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