Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil

Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil

Detalhes bibliográficos
Autores: Calvet, Guilherme Amaral, Velasque, Luciane de Souza, Luz, Paula Mendes, Cardoso, Sandra Wagner, Pedrosa, Monica Derrico, Moreira, Ronaldo Ismerio, Andrade, Angela Cristina Vasconcelos de, Cytryn, Andrea, Pires, Elaine, Veloso, Valdiléa G., Grinsztejn, Beatriz, Friedman, Ruth Khalili
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2014
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositório:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglês
OAI Identifier:oai:arca.fiocruz.br:icict/11092
Acesso em linha:https://arca.fiocruz.br/handle/icict/11092
Access Level:Acceso aberto
Palavra-chave:Antiretroviral Therapy
Premenopause
Postmenopause
HIV
Menopause
Anti-Retroviral Agents
Cohort Studies
Brazil/ethnology
Highly Active
Terapia Antirretroviral de Alta Atividade
Pré-Menopausa
Pós-Menopausa
Menopausa
Antirretrovirais
Estudos de Coortes
Brasil/etnologia
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oai_identifier_str oai:arca.fiocruz.br:icict/11092
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
title Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
spellingShingle Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
Calvet, Guilherme Amaral
Antiretroviral Therapy
Premenopause
Postmenopause
HIV
Menopause
Anti-Retroviral Agents
Cohort Studies
Brazil/ethnology
Highly Active
Terapia Antirretroviral de Alta Atividade
Pré-Menopausa
Pós-Menopausa
HIV
Menopausa
Antirretrovirais
Estudos de Coortes
Brasil/etnologia
title_short Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
title_full Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
title_fullStr Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
title_full_unstemmed Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
title_sort Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil
dc.creator.none.fl_str_mv Calvet, Guilherme Amaral
Velasque, Luciane de Souza
Luz, Paula Mendes
Cardoso, Sandra Wagner
Pedrosa, Monica Derrico
Moreira, Ronaldo Ismerio
Andrade, Angela Cristina Vasconcelos de
Cytryn, Andrea
Pires, Elaine
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Friedman, Ruth Khalili
author Calvet, Guilherme Amaral
author_facet Calvet, Guilherme Amaral
Velasque, Luciane de Souza
Luz, Paula Mendes
Cardoso, Sandra Wagner
Pedrosa, Monica Derrico
Moreira, Ronaldo Ismerio
Andrade, Angela Cristina Vasconcelos de
Cytryn, Andrea
Pires, Elaine
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Friedman, Ruth Khalili
author_role author
author2 Velasque, Luciane de Souza
Luz, Paula Mendes
Cardoso, Sandra Wagner
Pedrosa, Monica Derrico
Moreira, Ronaldo Ismerio
Andrade, Angela Cristina Vasconcelos de
Cytryn, Andrea
Pires, Elaine
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Friedman, Ruth Khalili
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.en.none.fl_str_mv Antiretroviral Therapy
Premenopause
Postmenopause
HIV
Menopause
Anti-Retroviral Agents
Cohort Studies
Brazil/ethnology
Highly Active
topic Antiretroviral Therapy
Premenopause
Postmenopause
HIV
Menopause
Anti-Retroviral Agents
Cohort Studies
Brazil/ethnology
Highly Active
Terapia Antirretroviral de Alta Atividade
Pré-Menopausa
Pós-Menopausa
HIV
Menopausa
Antirretrovirais
Estudos de Coortes
Brasil/etnologia
dc.subject.decs.none.fl_str_mv Terapia Antirretroviral de Alta Atividade
Pré-Menopausa
Pós-Menopausa
HIV
Menopausa
Antirretrovirais
Estudos de Coortes
Brasil/etnologia
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-07-06T13:06:45Z
dc.date.available.fl_str_mv 2015-07-06T13:06:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/11092
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0089299
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014.
1932-6203
10.1371/journal.pone.0089299
url https://arca.fiocruz.br/handle/icict/11092
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2015-07-06T13:06:45Z2015-07-06T13:06:45Z2014CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014.1932-6203https://arca.fiocruz.br/handle/icict/1109210.1371/journal.pone.00892991932-6203engPublic Library of ScienceAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Matemática e Estatística. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, BrasilObjective: To compare the effectiveness of first-line combination antiretroviral therapy (cART) between premenopausal and postmenopausal women. Methods: ART-naı¨ve women initiating cART between January 2000/June 2010 at the Instituto de Pesquisa Clı´nica Evandro Chagas Cohort were studied. Women were defined as postmenopausal after 12 consecutive months of amenorrhea. CD4 cell counts and HIV-1 RNA viral load (VL) measurements were compared between pre- and postmenopausal at 6, 12 and 24 months after cART initiation. Women who modified/discontinued a drug class or died due to an AIDS defining illness were classified as ART-failures. Variables were compared using Wilcoxon test, x2 or Fisher's exact test. The odds of cART effectiveness (VL,400 copies/mL and/or no need to change cART) were compared using logistic regression. Linear model was used to access relationship between CD4 change and menopause. Results: Among 383 women, 328 (85%) were premenopausal and 55 (15%) postmenopausal. Median pre cART CD4 counts were 231 and 208 cells/mm3 (p=0.14) in pre- and postmenopausal women, respectively. No difference in the median pre cART VL was found (both 4.8 copies/mL). Median CD4 changes were similar at 6 and 12 months. At 24 months after cART initiation, CD4 changes among postmenopausal women were significantly lower among premenopausal women (p=0.01). When the analysis was restricted to women with VL,400 copies/mL, no statistical difference was observed. Overall, 63.7% achieved cART effectiveness at 24 months without differences between groups at 6, 12 and 24 months. Conclusion: Menopause status at the time of first-line cART initiation does not impact CD4 cell changes at 24 months among women with a virologic response. No relationship between menopause status and virologic response was observed.Antiretroviral TherapyPremenopausePostmenopauseHIVMenopauseAnti-Retroviral AgentsCohort StudiesBrazil/ethnologyHighly ActiveTerapia Antirretroviral de Alta AtividadePré-MenopausaPós-MenopausaHIVMenopausaAntirretroviraisEstudos de CoortesBrasil/etnologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZCalvet, Guilherme AmaralVelasque, Luciane de SouzaLuz, Paula MendesCardoso, Sandra WagnerPedrosa, Monica DerricoMoreira, Ronaldo IsmerioAndrade, Angela Cristina Vasconcelos deCytryn, AndreaPires, ElaineVeloso, Valdiléa G.Grinsztejn, BeatrizFriedman, Ruth KhaliliLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://arca.fiocruz.br/bitstreams/48090bbd-1ba4-4624-bf43-2598ddd8bfb4/download8b4c200b4e10021c5683c6ccaba07169MD51falseAnonymousREADORIGINALAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdfAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdfapplication/pdf104692https://arca.fiocruz.br/bitstreams/cd70bbe0-81f0-456b-8731-3369f2487dbd/download5af38dd1e354452d045751ee4890aa9eMD52trueAnonymousREADTEXTAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.txtAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.txtExtracted texttext/plain35740https://arca.fiocruz.br/bitstreams/44aa5a5f-f12c-4138-838e-a637e7df45e1/download26a7099410105c5d3665556a841a9801MD511falseAnonymousREADTHUMBNAILAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.jpgAbsence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses A cohort study from Rio de Janeiro, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg49892https://arca.fiocruz.br/bitstreams/b59c3822-1ff3-4f2a-abc1-b8e52793b87f/download40bbb674d49c6991f39c503a5a4c10ebMD512falseAnonymousREADicict/110922025-12-10 13:00:24.109open.accessoai:arca.fiocruz.br:icict/11092https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T16:00:24Repositório Institucional da FIOCRUZ (ARCA) - 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