The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution

Sepsis is described as a life-threatening organ dysfunction caused by a host’s response to infection, leading to an unbalance in body homeostasis. It is one of the leading causes of death in developed countries. Considering that in critically ill patients, such as those with sepsis, plasma concentra...

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Autores: Borges, Karolina Torres Santos, Henz, Pricilla, Araújo, Bibiana Verlindo de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Brazilian Journal of Pharmaceutical Sciences
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/227781
Acceso en línea:https://www.revistas.usp.br/bjps/article/view/227781
Access Level:acceso abierto
Palabra clave:Sepsis
Antimicrobials
Microdialysis
Tissue penetration
Pharmacokinetics
Pharmacodynamics
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spelling The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distributionSepsisAntimicrobialsMicrodialysisTissue penetrationPharmacokineticsPharmacodynamicsSepsis is described as a life-threatening organ dysfunction caused by a host’s response to infection, leading to an unbalance in body homeostasis. It is one of the leading causes of death in developed countries. Considering that in critically ill patients, such as those with sepsis, plasma concentrations do not necessarily reflect tissue concentrations, one way to assess tissue concentrations is through the microdialysis technique, which allows direct measurements of free drug at the site of action. This review was carried out after searching the Pubmed, Scielo and Web of Science databases, using the following descriptors: (microdialysis AND (sepsis OR septic shock OR severe sepsis OR septicemia)) OR (microdialysis AND (sepsis OR septic shock OR severe sepsis) OR septicemia) AND (antimicrobial OR antibiotic OR antifungal)). The physiological changes generated by sepsis may imply changes in pharmacokinetic parameters, such as in clearance, which may be reduced in these patients and in volume of distribution, which presents an expansion, mainly due to edema. Both events contribute to a high inter- individual variability in tissue penetration of antimicrobials which is generally observed in patients with sepsis.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-11-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/22778110.1590/Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e22982Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e22982Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e229822175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/227781/206284Copyright (c) 2023 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBorges, Karolina Torres SantosHenz, PricillaAraújo, Bibiana Verlindo de2024-08-14T13:06:15Zoai:revistas.usp.br:article/227781Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2024-08-14T13:06:15Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
title The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
spellingShingle The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
Borges, Karolina Torres Santos
Sepsis
Antimicrobials
Microdialysis
Tissue penetration
Pharmacokinetics
Pharmacodynamics
title_short The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
title_full The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
title_fullStr The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
title_full_unstemmed The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
title_sort The influence of sepsis on antimicrobials tissue penetration: the use of microdialysis technique to access free drug distribution
dc.creator.none.fl_str_mv Borges, Karolina Torres Santos
Henz, Pricilla
Araújo, Bibiana Verlindo de
author Borges, Karolina Torres Santos
author_facet Borges, Karolina Torres Santos
Henz, Pricilla
Araújo, Bibiana Verlindo de
author_role author
author2 Henz, Pricilla
Araújo, Bibiana Verlindo de
author2_role author
author
dc.subject.por.fl_str_mv Sepsis
Antimicrobials
Microdialysis
Tissue penetration
Pharmacokinetics
Pharmacodynamics
topic Sepsis
Antimicrobials
Microdialysis
Tissue penetration
Pharmacokinetics
Pharmacodynamics
description Sepsis is described as a life-threatening organ dysfunction caused by a host’s response to infection, leading to an unbalance in body homeostasis. It is one of the leading causes of death in developed countries. Considering that in critically ill patients, such as those with sepsis, plasma concentrations do not necessarily reflect tissue concentrations, one way to assess tissue concentrations is through the microdialysis technique, which allows direct measurements of free drug at the site of action. This review was carried out after searching the Pubmed, Scielo and Web of Science databases, using the following descriptors: (microdialysis AND (sepsis OR septic shock OR severe sepsis OR septicemia)) OR (microdialysis AND (sepsis OR septic shock OR severe sepsis) OR septicemia) AND (antimicrobial OR antibiotic OR antifungal)). The physiological changes generated by sepsis may imply changes in pharmacokinetic parameters, such as in clearance, which may be reduced in these patients and in volume of distribution, which presents an expansion, mainly due to edema. Both events contribute to a high inter- individual variability in tissue penetration of antimicrobials which is generally observed in patients with sepsis.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/227781
10.1590/
url https://www.revistas.usp.br/bjps/article/view/227781
identifier_str_mv 10.1590/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/227781/206284
dc.rights.driver.fl_str_mv Copyright (c) 2023 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e22982
Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e22982
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e22982
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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