Efeito da infecção hospitalar da corrente sanguínea por Staphylococcus aureus resistente à oxacilina sobre a letalidade e o tempo de hospitalização

OBJECTIVES: To identify the attributed mortality rate of bloodstream hospital infection by Staphylococcus aureus resistant to methicillin (MRSA) and its effect on length of hospital stay. DESIGN:Case-control study SETTING: Hospital São Paulo da Universidade Federal de São Paulo (UNIFESP), a 660-bed,...

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Detalles Bibliográficos
Autores: Moreira, M. [UNIFESP], Medeiros, Eduardo Alexandrino Servolo de [UNIFESP], Pignatari, Antonio Carlos Campos [UNIFESP], Wey, Sergio Barsanti [UNIFESP], Cardo, D.m. [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1998
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:portugués
OAI Identifier:oai:repositorio.unifesp.br:11600/699
Acceso en línea:http://dx.doi.org/10.1590/S0104-42301998000400002
http://repositorio.unifesp.br/handle/11600/699
Access Level:acceso abierto
Palabra clave:Sepsis
Mortality
Staphylococcus aureus
Cross infection
Sepses
Mortalidade
Infecção hospitalar
Descripción
Sumario:OBJECTIVES: To identify the attributed mortality rate of bloodstream hospital infection by Staphylococcus aureus resistant to methicillin (MRSA) and its effect on length of hospital stay. DESIGN:Case-control study SETTING: Hospital São Paulo da Universidade Federal de São Paulo (UNIFESP), a 660-bed, tertiary-care teaching hospital in São Paulo, Brazil. PATIENTS: Seventy one adults patients with hospital-acquired MRSA bacteremia diagnosed between January 1, 1991, and September 30, 1992, and 71 MRSA-free controls were matched by the following criteria: age, sex, underlying disease, surgical procedure, same risk time and admissiom date. RESULTS: The incidence of patients with hospital sepsis by MRSA accounted for 73.22% of the patients with hospital bloodstream infection by Staphylococcus aureus . The mortality rate of the cases was 56.33 (40/71) and 11.26 (8/71) of the controls. The attributable mortality rate was 45.07% (OR=17.0; IC 95%=3.58 -- 202.26; p=0.000001). The length of hospital stay median time was of 32.55 days for the cases and 29.75 for the controls (p = 0.32). CONCLUSION: A high level of sepsis by MRSA was observed in all the Staphylococcus aureus bacteremia. The bloodstream hospital infection by MRSA itself does provide a high level of mortality independently from the patients base disease, without however, increasing their hospital length of stay.